Evidence map›Paper›PMID 37235809›Full record

ArticleJournal of medicinal chemistry2023

Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.

Satish R Malwal, Ben Mazurek, Jihee Ko, Pujun Xie, Chikako Barnes, Christine Varvitsiotis, Matthew D Zimmerman, Samir Olatunji, Jaeyong Lee, Min Xie and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Common Biological Properties ofACS infectious diseases · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Satish R MalwalDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-7606-1932
Ben MazurekDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-8555-4963
Jihee KoDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-7970-1509
Pujun XieDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Chikako BarnesDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Christine VarvitsiotisDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Matthew D ZimmermanCenter for Discovery and Innovation, 111 Ideation Way, Nutley, New Jersey 07110, United States.
Samir OlatunjiSchools of Medicine and Biochemistry & Immunology, Trinity College, Dublin D02 R590, Ireland.
Jaeyong LeeDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Min XieCenter for Discovery and Innovation, 111 Ideation Way, Nutley, New Jersey 07110, United States.
Jansy SarathyCenter for Discovery and Innovation, 111 Ideation Way, Nutley, New Jersey 07110, United States.
Martin CaffreySchools of Medicine and Biochemistry & Immunology, Trinity College, Dublin D02 R590, Ireland.
Natalie C J StrynadkaDepartment of Biochemistry and Molecular Biology and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.ORCID 0000-0002-4058-9425
Véronique DartoisCenter for Discovery and Innovation, 111 Ideation Way, Nutley, New Jersey 07110, United States.ORCID 0000-0001-9470-5009
Thomas DickCenter for Discovery and Innovation, 111 Ideation Way, Nutley, New Jersey 07110, United States.
Bom Nae Rin LeeDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, United States.
David G RussellDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, United States.
Eric OldfieldDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-0996-7352
University of Illinois Urbana-Champaign · USCenter for Discovery · USCornell University · USTrinity College Dublin · IEUniversity of British Columbia · CAGeorgetown University · US

Funding

Systems Biology CoreU19AI162598 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI DIETZE, REYNALDO · 2021 to 2025
$13.9M
Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
NIAID NIH HHS R01 AI132374NIAID NIH HHS U19 AI162598
6 · The paper itself

Abstract

We tested a series of SQ109 analogues against

Indexed as

Mycobacterium tuberculosisTuberculosisAdamantaneAntitubercular AgentsDiphosphatesEthylenediaminesHumansMycobacterium smegmatisAdamantaneAntitubercular AgentsDiphosphatesEthylenediaminesN-geranyl-N'-(2-adamantyl)ethane-1,2-diamine

Identifiers

PMID37235809
PMCPMC10330530
OpenAlexW4378363830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.