Evidence map›Paper›PMID 37235776›Full record

ArticleACS chemical neuroscience2023

Total Chemical Synthesis of Glycosylated TREM2 Ectodomain.

Gayani Wijegunawardena, Erika Castillo, Brandy Henrickson, Regan Davis, Carlo Condello, Haifan Wu

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gayani WijegunawardenaDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Erika CastilloInstitute for Neurodegenerative Diseases, University of California, San Francisco, California 94158, United States.ORCID 0000-0003-2492-901X
Brandy HenricksonDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Regan DavisDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.
Carlo CondelloInstitute for Neurodegenerative Diseases, University of California, San Francisco, California 94158, United States.
Haifan WuDepartment of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.ORCID 0000-0002-2050-9950
Wichita State University · USUniversity of California, San Francisco · US

Funding

VIRAL DEGENERATIVE DEMENTING DISEASE IN AGING (SUPP)P01AG002132 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRUSINER, STANLEY B · 1985 to 2024
$51.7M
Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's DiseaseRF1AG061874 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONDELLO, CARLO L, DEGRADO, WILLIAM · 2018 to 2018
$2.0M
Chemical Tools to Target TREM2 in Alzheimer's DiseaseR15AG080493 · NIA · WICHITA STATE UNIVERSITY · PI WU, HAIFAN · 2023 to 2023
$412k
NIA NIH HHS P01 AG002132NIA NIH HHS R15 AG080493NIA NIH HHS RF1 AG061874NIGMS NIH HHS P20 GM113117NIGMS NIH HHS R24 GM137786
6 · The paper itself

Abstract

Mutations in a microglia-associated gene

Indexed as

Alzheimer DiseaseAnimalsGlycosylationHumansMammalsMembrane GlycoproteinsMicrogliaMutationPhagocytosisReceptors, ImmunologicMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanAlzheimer’s diseaseglycosylationnative chemical ligationTREM2

Identifiers

PMID37235776
PMCPMC10786670
OpenAlexW4378373495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.