ArticleScience advances2023
Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Translational relevance of animal models available on brain arteriovenous malformations, a systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Pooled it
- Presentation and management of cerebral proliferative angiopathy: a systematic review and meta-analysis on treatment outcomes.Neurosurgical review · 2024Pooled it
- Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.Annals of the rheumatic diseases · 2026Article
- Towards precision medicine for brain arteriovenous malformations.The Journal of clinical investigation · 2026Review
- Arterial Endothelial Deletion ofCirculation research · 2026Article
- Advances in the Genetics and Molecular Biology of Brain Arteriovenous Malformations.Translational stroke research · 2026Review
- Review
- AIBP-LRP2-mediated HDL uptake restricts CXCR4Science advances · 2025Article
- PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations.Circulation · 2025Article
- Neuroinflammation and hypoxia promote astrocyte phenotypic transformation and propel neurovascular dysfunction in brain arteriovenous malformation.Journal of neuroinflammation · 2025Article
- Small molecule probes for peroxynitrite detection.Redox biochemistry and chemistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 1 country.
Lawrence HuangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-9074-4510
Feng ChengLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-5672-5578
Xuetao ZhangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Jacek ZielonkaFree Radical Research Laboratory, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-2524-0145
Matthew A NystoriakDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0001-8872-158X
Weiwei XiangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-3131-7970
Kunal RaygorLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-5517-7706
Shaoxun WangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Aditya LakshmananLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-6927-1066
Weiya JiangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Sai YuanLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-4089-5780
Kevin S HouLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Jiayi ZhangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Xitao WangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
Arsalan U SyedDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Matea JuricFree Radical Research Laboratory, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-5031-8285
Takamune TakahashiDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-4841-2499
Manuel F NavedoDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0001-6864-6594
Rong A WangLaboratory for Accelerated Vascular Research, Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-7882-2475
University of California, San Francisco · USUniversity of California, Davis · USMedical College of Wisconsin · USVanderbilt University Medical Center · US
Funding
Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5MNotch Signaling in Mouse Arterial-Venous SpecificationR01HL075033 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, RONG · 2005 to 2015
$3.7MCalcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5MRegulation of Coronary Blood FlowR01HL142710 · NHLBI · UNIVERSITY OF LOUISVILLE · PI NYSTORIAK, MATTHEW A · 2018 to 2022
$3.1MCerebral Vascular Smooth Muscle Dysfunction in Alzheimer's DiseaseR01HL149127 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2019 to 2022
$2.7McAMP signaling in vascular smooth muscle in health and diseaseR01HL161872 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2022 to 2025
$2.6MMolecular Pathogenesis of Brain Arteriovenous MalformationR01NS067420 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, RONG · 2010 to 2018
$2.3MMolecular Pathogenesis of Hereditary Hemorrhagic TelangiectasiaR01NS113429 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, RONG · 2020 to 2024
$2.3MMolecular pathogenesis of brain arteriovenous malformationR56NS067420 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, RONG · 2013 to 2013
$404kNHLBI NIH HHS R01 HL075033NHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL142710NHLBI NIH HHS R01 HL149127NHLBI NIH HHS R01 HL161872NINDS NIH HHS R01 NS067420NINDS NIH HHS R01 NS113429NINDS NIH HHS R56 NS067420
Abstract
Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*
Indexed as
Arteriovenous MalformationsHydrogen PeroxideNitric Oxide Synthase Type IIIAnimalsArteriesMiceNitric Oxide SynthaseNitroarginineHydrogen PeroxideNitric Oxide SynthaseNitric Oxide Synthase Type IIINitroarginine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.