ArticleScience advances2023
Transformation of arginine into zero-dimensional nanomaterial endows the material with antibacterial and osteoinductive activity.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Advances in the Application of Multimodal Nano-Antimicrobial Strategies in Prosthetic Joint Infections: A Systematic Review.International journal of nanomedicine · 2025Pooled it
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- Disease-Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Carbon Dot-Linked Hydrogel-Composite Scaffold with Sequential Release of Multi-Drug for Bone Repair.Gels (Basel, Switzerland) · 2026Article
- Engineering L-Arg@ZIF-8 nanoparticles to modulate the immune-osteogenic-angiogenic microenvironment for accelerated bone fracture healing.Discover nano · 2026Article
- A comprehensive review of carbon dots for antimicrobial therapy: from design mechanisms to theranostic applications.Discover nano · 2026Review
- Immune regulative GelMA&ZnBioactive materials · 2026Article
- Functionalized GelMA-based hydrogels for osteoimmunomodulation and bone regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Targeting JAK2 with a multifunctional nanoinhibitor for long-lasting anti-inflammatory effects and bone repair.Journal of nanobiotechnology · 2025Article
- Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation.Bioactive materials · 2025Article
- A natural biological adhesive from slug mucus for wound repair.Bioactive materials · 2025Article
- Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges.Biomedical engineering online · 2025Review
- Acid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- On-demand imidazolidinyl urea-based tissue-like, self-healable, and antibacterial hydrogels for infectious wound care.Bioactive materials · 2025Article
- Nanostructure-Mediated Photothermal Effect for Reinforcing Physical Killing Activity of Nanorod Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Hydrogel-based therapies for diabetic foot ulcers: recent developments and clinical implications.Burns & trauma · 2025Review
- A three-phase strategy of bionic drug reservoir scaffold by 3D printing and layer-by-layer modification for chronic relapse management in traumatic osteomyelitis.Materials today. Bio · 2024Article
- A novel multifunctional nanocomposite hydrogel orchestrates the macrophage reprogramming-osteogenesis crosstalk to boost bone defect repair.Journal of nanobiotechnology · 2024Article
- The microneedle bandages provide new hope for healing diabetic wounds.Acta pharmaceutica Sinica. B · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implant-associated infection is a major threat affecting the success of orthopedic surgeries. Although various materials scavenge bacteria by generating reactive oxygen species (ROS), the intrinsic inability of ROS to distinguish bacteria from cells notably limits the therapeutic effects. Here, we found that the arginine carbon dots (Arg-CDs) that were transformed from arginine exhibited supreme antibacterial and osteoinductive activity. We further designed the Schiff base bond between Arg-CDs and aldehyde hyaluronic acid/gelatin methacryloyl (HG) hydrogel to release Arg-CDs in response to the acidic bone injury microenvironment. The free Arg-CDs could selectively kill bacteria by generating excessive ROS. Furthermore, the Arg-CD-loaded HG composite hydrogel showed excellent osteoinductive activity through inducing the M2 polarization of macrophages by up-regulating interleukin-10 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.