Evidence map›Paper›PMID 37235367›Full record

ArticleToxins2023

Pain Reduction in Cervical Dystonia Following Treatment with IncobotulinumtoxinA: A Pooled Analysis.

Alberto Albanese, Jörg Wissel, Wolfgang H Jost, Anna Castagna, Michael Althaus, Georg Comes, Astrid Scheschonka, Matteo Vacchelli, Hyder A Jinnah

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Impact of Physiotherapy in the Treatment of Pain in Cervical Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Alberto AlbaneseDepartment of Neurology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy.
Jörg WisselDepartment of Neurorehabilitation and Physical Therapy, Vivantes Hospital Spandau, 13585 Berlin, Germany.ORCID 0000-0001-6238-3578
Wolfgang H JostParkinson-Klinik Ortenau, 77709 Wolfach, Germany.ORCID 0000-0002-8574-3297
Anna CastagnaIRCCS Fondazione Don Carlo Gnocchi, 20148 Milano, MI, Italy.
Michael AlthausMerz Therapeutics GmbH, 60318 Frankfurt am Main, Germany.
Georg ComesMerz Therapeutics GmbH, 60318 Frankfurt am Main, Germany.
Astrid ScheschonkaMerz Therapeutics GmbH, 60318 Frankfurt am Main, Germany.ORCID 0000-0003-4745-0853
Matteo VacchelliMerz Therapeutics GmbH, 60318 Frankfurt am Main, Germany.
Hyder A JinnahDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Don Carlo Gnocchi Foundation · ITEmory University · USIRCCS Humanitas Research Hospital · ITParkinson-Klinik Ortenau · DEVivantes Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This analysis pooled pain severity data from four phase 3 and 4 studies of incobotulinumtoxinA (incoBoNT-A) for the treatment of cervical dystonia (CD) in adults. CD-related pain severity was assessed at baseline, each injection visit, and 4 weeks after each injection of incoBoNT-A using the Toronto Western Spasmodic Torticollis Rating Scale pain severity subscale or a pain visual analog scale. Both were analyzed using a score range of 0-10 and pain was categorized as mild, moderate, or severe. Data for 678 patients with pain at baseline were assessed and sensitivity analyses evaluated pain responses in the subgroup not taking concomitant pain medication (

Indexed as

Botulinum Toxins, Type ANeuromuscular AgentsTorticollisAdultHumansPain ManagementPain MeasurementTreatment OutcomeBotulinum Toxins, Type AincobotulinumtoxinANeuromuscular Agentsbotulinum toxin type Acervical dystoniaincobotulinumtoxinApainpooled analysis

Identifiers

PMID37235367
PMCPMC10224129
OpenAlexW4376275210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.