Evidence map›Paper›PMID 37235362›Full record

ArticleToxins2023

LC-MS/MS Analysis of Cyanotoxins in Bivalve Mollusks-Method Development, Validation and First Evidence of Occurrence of Nodularin in Mussels (

Julio César España Amórtegui, Heidi Pekar, Mark Dennis Chico Retrato, Malin Persson, Bengt Karlson, Jonas Bergquist, Aida Zuberovic-Muratovic

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Julio César España AmórteguiScience Department, Swedish Food Agency, Box 622, SE-751 26 Uppsala, Sweden.ORCID 0000-0003-3566-5689
Heidi PekarScience Department, Swedish Food Agency, Box 622, SE-751 26 Uppsala, Sweden.
Mark Dennis Chico RetratoDepartment of Chemistry, Biomedical Center, Analytical Chemistry and Neurochemistry, Uppsala University, Box 599, SE-751 24 Uppsala, Sweden.ORCID 0000-0001-9682-6840
Malin PerssonScience Department, Swedish Food Agency, Box 622, SE-751 26 Uppsala, Sweden.
Bengt KarlsonResearch and Development, Oceanography, Swedish Meteorological and Hydrological Institute, Sven Källfelts Gata 15, SE-426 71 Västra Frölunda, Sweden.ORCID 0000-0002-7524-3504
Jonas BergquistDepartment of Chemistry, Biomedical Center, Analytical Chemistry and Neurochemistry, Uppsala University, Box 599, SE-751 24 Uppsala, Sweden.ORCID 0000-0002-4597-041X
Aida Zuberovic-MuratovicScience Department, Swedish Food Agency, Box 622, SE-751 26 Uppsala, Sweden.
National Food Administration · SEUppsala University · SESwedish Meteorological and Hydrological Institute · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, an LC-MS/MS method for the simultaneous identification and quantification of cyanotoxins with hydrophilic and lipophilic properties in edible bivalves is presented. The method includes 17 cyanotoxins comprising 13 microcystins (MCs), nodularin (NOD), anatoxin-a (ATX-a), homoanatoxin (h-ATX) and cylindrospermopsin (CYN). A benefit to the presented method is the possibility for the MS detection of MC-LR-[Dha7] and MC-LR-[Asp3] as separately identified and MS-resolved MRM signals, two congeners which were earlier detected together. The performance of the method was evaluated by in-house validation using spiked mussel samples in the quantification range of 3.12-200 µg/kg. The method was found to be linear over the full calibration range for all included cyanotoxins except CYN for which a quadratic regression was used. The method showed limitations for MC-LF (R

Indexed as

Mytilus edulisOstreidaeAnimalsChromatography, LiquidCyanobacteria ToxinsMicrocystinsPeptides, CyclicSeafoodSwedenTandem Mass SpectrometryCyanobacteria ToxinsMicrocystinsnodularinPeptides, CyclicbivalvescyanotoxinsLC-MS/MSmusselsnodularinseafood safety

Identifiers

PMID37235362
PMCPMC10221150
OpenAlexW4376137860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.