Evidence map›Paper›PMID 37235269›Full record

ArticleToxics2023

Maternal Serum, Cord and Human Milk Levels of Per- and Polyfluoroalkyl Substances (PFAS), Association with Predictors and Effect on Newborn Anthropometry.

Maya Mahfouz, Mireille Harmouche-Karaki, Joseph Matta, Yara Mahfouz, Pascale Salameh, Hassan Younes, Khalil Helou, Ramzi Finan, Georges Abi-Tayeh, Mohamad Meslimani and 5 more

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Maya MahfouzDepartment of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Medical Sciences Campus, Damascus Road, P.O. Box 115076, Riad Solh Beirut 1107 2180, Lebanon.ORCID 0000-0003-1901-5707
Mireille Harmouche-KarakiDepartment of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Medical Sciences Campus, Damascus Road, P.O. Box 115076, Riad Solh Beirut 1107 2180, Lebanon.ORCID 0000-0002-8205-4955
Joseph MattaIndustrial Research Institute, Lebanese University Campus, Hadath Baabda P.O. Box 112806, Lebanon.
Yara MahfouzDepartment of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Medical Sciences Campus, Damascus Road, P.O. Box 115076, Riad Solh Beirut 1107 2180, Lebanon.ORCID 0000-0001-7062-1302
Pascale SalamehSchool of Medicine, Lebanese American University, Byblos 1102 2801, Lebanon.
Hassan YounesInstitut Polytechnique UniLaSalle, Collège Santé, Equipe PANASH, Membre de l'ULR 7519, Université d'Artois, 19 Rue Pierre Waguet, 60026 Beauvais, France.ORCID 0000-0002-6633-8659
Khalil HelouDepartment of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Medical Sciences Campus, Damascus Road, P.O. Box 115076, Riad Solh Beirut 1107 2180, Lebanon.
Ramzi FinanHotel-Dieu de France, Saint Joseph University of Beirut Hospital, Blvd Alfred Naccache, Beirut P.O. Box 166830, Lebanon.
Georges Abi-TayehHotel-Dieu de France, Saint Joseph University of Beirut Hospital, Blvd Alfred Naccache, Beirut P.O. Box 166830, Lebanon.
Mohamad MeslimaniGeneral Management, Chtoura Hospital, Beqaa, Lebanon.
Ghada MoussaDepartment of Obstetrics and Gynecology, Chtoura Hospital, Beqaa, Lebanon.
Nada ChahrourDepartment of Obstetrics and Gynecology, SRH University Hospital, Nabatieh, Lebanon.
Camille OsseiranDepartment of Obstetrics and Gynecology, Kassab Hospital, Saida, Lebanon.
Farouk SkaikiDepartment of Molecular Biology, General Management, Al Karim Medical Laboratories, Saida, Lebanon.
Jean-François NarbonneLaboratoire de Physico-Toxico Chimie des Systèmes Naturels, University of Bordeaux, CEDEX, 33405 Talence France.
Saint Joseph University · LBLebanese American University · LBLebanese University · LBUniversité d'Artois · FRUniversité de Bordeaux · FR

Funding

Saint Joseph University FPH77
6 · The paper itself

Abstract

backgroundThe understanding of per- and polyfluoroalkyl substances (PFAS) health effects is rapidly advancing among critical populations. Therefore, the objective of this study was to assess PFAS serum levels among Lebanese pregnant women, cord serum and human milk levels, their determinants, and effects on newborn anthropometry.

methodsWe measured concentrations of six PFAS (PFHpA, PFOA, PFHxS, PFOS, PFNA and PFDA) using liquid chromatography MS/MS for 419 participants, of which 269 had sociodemographic, anthropometric, environmental and dietary information.

resultsThe percentage of detection for PFHpA, PFOA, PFHxS and PFOS was 36.3-37.7%. PFOA and PFOS levels (95th percentile) were higher than HBM-I and HBM-II values. While PFAS were not detected in cord serum, five compounds were detected in human milk. Multivariate regression showed that fish/shellfish consumption, vicinity to illegal incineration and higher educational level were associated with an almost twice higher risk of elevated PFHpA, PFOA, PFHxS and PFOS serum levels. Higher PFAS levels in human milk were observed with higher eggs and dairy products consumption, in addition to tap water (preliminary findings). Higher PFHpA was significantly associated with lower newborn weight-for-length Z-score at birth.

conclusionsFindings establish the need for further studies, and urgent action to reduce exposure among subgroups with higher PFAS levels.

Indexed as

cordexposure predictorshuman biomonitoringhuman milknewbornperinatal exposurepersistent organic pollutantspregnant women

Identifiers

PMID37235269
PMCPMC10223184
OpenAlexW4376614540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.