Evidence map›Paper›PMID 37235195›Full record

ArticleTopics in spinal cord injury rehabilitation2023

Differential Expression of Vascular-Related MicroRNA in Circulating Endothelial Microvesicles in Adults With Spinal Cord Injury: A Pilot Study.

Andrew J Park, Hannah K Fandl, Vinicius P Garcia, Geoff B Coombs, Noah M DeSouza, Jared J Greiner, Otto F Barak, Tanja Mijacika, Zeljko Dujic, Philip N Ainslie and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Topics in spinal cord injury rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06379711 (Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06379711 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury

TypeinterventionalSponsorUniversity of British ColumbiaRan2024 to 2028Enrolled22ConditionsSpinal Cord Injuries, Cardiovascular Diseases, Cardiopulmonary DiseasesArmsTranscutaneous Spinal Cord Stimulation (tSCS)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Andrew J ParkRocky Mountain Regional Spinal Injury System, Craig Hospital, Englewood, Colorado.
Hannah K FandlIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Vinicius P GarciaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Geoff B CoombsUniversity of Western Ontario, School of Kinesiology, London, Ontario, Canada.
Noah M DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Jared J GreinerIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
Otto F BarakDepartment of Sports Medicine, University of Novi Sad, Serbia.
Tanja MijacikaDepartment of Integrative Physiology, University of Split School of Medicine, Split, Croatia.
Zeljko DujicDepartment of Integrative Physiology, University of Split School of Medicine, Split, Croatia.
Philip N AinslieCentre for Heart, Lung and Vascular Health, University of British Columbia Okanagan, Kelowna, British Columbia, Canada.
Christopher A DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
University of Colorado Boulder · USUniversity of Split · HRCraig Hospital · USOkanagan University College · CAUniversity of British Columbia · CAUniversity of Novi Sad · RSWestern University · CA

Funding

Molecular and Functional Mechanisms of Pediatric Heart FailureR01HL107715 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STAUFFER, BRIAN L · 2012 to 2016
$2.8M
Aging, Exercise and Endothelin-1 Vasoconstrictor ToneR01HL077450 · NHLBI · UNIVERSITY OF COLORADO AT BOULDER · PI DESOUZA, CHRISTOPHER A · 2004 to 2007
$1.4M
NHLBI NIH HHS R01 HL077450NHLBI NIH HHS R01 HL107715
6 · The paper itself

Abstract

Background: Spinal cord injury (SCI) is associated with an increased risk and prevalence of cardiopulmonary and cerebrovascular disease-related morbidity and mortality. The factors that initiate, promote, and accelerate vascular diseases and events in SCI are poorly understood. Clinical interest in circulating endothelial cell-derived microvesicles (EMVs) and their microRNA (miRNA) cargo has intensified due to their involvement in endothelial dysfunction, atherosclerosis, and cerebrovascular events. Objectives: The aim of this study was to determine whether a subset of vascular-related miRNAs is differentially expressed in EMVs isolated from adults with SCI. Methods: We assessed eight adults with tetraplegia (7 male/1 female; age: 46±4 years; time since injury: 26±5 years) and eight uninjured (6 male/2 female; age: 39±3 years). Circulating EMVs were isolated, enumerated, and collected from plasma by flow cytometry. The expression of vascular-related miRNAs in EMVs was assessed by RT-PCR. Results: Circulating EMV levels were significantly higher (~130%) in adults with SCI compared with uninjured adults. The expression profile of miRNAs in EMVs from adults with SCI were significantly different than uninjured adults and were pathologic in nature. Expression of miR-126, miR-132, and miR-Let-7a were lower (~100-150%; Conclusion: This study is the first examination of EMV miRNA cargo in adults with SCI. The cargo signature of vascular-related miRNAs studied reflects a pathogenic EMV phenotype prone to induce inflammation, atherosclerosis, and vascular dysfunction. EMVs and their miRNA cargo represent a novel biomarker of vascular risk and a potential target for intervention to alleviate vascular-related disease after SCI.

Indexed as

AtherosclerosisCell-Derived MicroparticlesMicroRNAsSpinal Cord InjuriesFemaleHumansMalePilot ProjectsMicroRNAsMIRN145 microRNA, humancardiovascular diseaseendothelial microvesiclesmicroRNAspinal cord injury

Identifiers

PMID37235195
PMCPMC10208256
OpenAlexW4362581023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.