Evidence map›Paper›PMID 37235192›Full record

ArticleTopics in spinal cord injury rehabilitation2023

A Scoping Review of Epidural Spinal Cord Stimulation for Improving Motor and Voiding Function Following Spinal Cord Injury.

Nina D'hondt, Karmi Margaret Marcial, Nimish Mittal, Matteo Costanzi, Yasmine Hoydonckx, Pranab Kumar, Marina F Englesakis, Anthony Burns, Anuj Bhatia

Open access · greenAbstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Topics in spinal cord injury rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Nina D'hondtDepartment of Pain Medicine, Multidisciplinary Pain Center, VITAZ, Sint-Niklaas, Belgium.
Karmi Margaret MarcialDepartment of Anesthesiology, Philippine General Hospital, University of Philippines, Philippines.
Nimish MittalDepartment of Physical Medicine and Rehabilitation, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Matteo CostanziDepartment of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Yasmine HoydonckxDepartment of Anesthesiology and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Pranab KumarDepartment of Anesthesiology and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Marina F EnglesakisMLIS Library & Information Services, University Health Network, Toronto, Ontario, Canada.
Anthony BurnsDepartment of Physical Medicine and Rehabilitation, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Anuj BhatiaDepartment of Anesthesiology and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CAUniversity Health Network · CAAgostino Gemelli University Polyclinic · ITPhilippine General Hospital · PHVlaamse Vereniging voor Obstetrie en Gynaecolo · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To identify and synthesize the existing evidence on the effectiveness and safety of epidural spinal cord stimulation (SCS) for improving motor and voiding function and reducing spasticity following spinal cord injury (SCI). Methods: This scoping review was performed according to the framework of Arksey and O'Malley. Comprehensive serial searches in multiple databases (MEDLINE, Embase, Cochrane Central, Cochrane Database of Systematic Reviews, LILACS, PubMed, Web of Science, and Scopus) were performed to identify relevant publications that focused on epidural SCS for improving motor function, including spasticity, and voiding deficits in individuals with SCI. Results: Data from 13 case series including 88 individuals with complete or incomplete SCI (American Spinal Injury Association Impairment Scale [AIS] grade A to D) were included. In 12 studies of individuals with SCI, the majority (83 out of 88) demonstrated a variable degree of improvement in volitional motor function with epidural SCS. Two studies, incorporating 27 participants, demonstrated a significant reduction in spasticity with SCS. Two small studies consisting of five and two participants, respectively, demonstrated improved supraspinal control of volitional micturition with SCS. Conclusion: Epidural SCS can enhance central pattern generator activity and lower motor neuron excitability in individuals with SCI. The observed effects of epidural SCS following SCI suggest that the preservation of supraspinal transmission is sufficient for the recovery of volitional motor and voiding function, even in patients with complete SCI. Further research is warranted to evaluate and optimize the parameters for epidural SCS and their impact on individuals with differing degrees of severity of SCI.

Indexed as

Spinal Cord InjuriesSpinal Cord StimulationHumansMuscle SpasticityUrinationbladder functionmotor functionspasticityspinal cord injuryspinal cord stimulation

Identifiers

PMID37235192
PMCPMC10208259
OpenAlexW4377970180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.