Evidence map›Paper›PMID 37235059›Full record

ArticleiScience2023

Restoration of normal blood flow in atherosclerotic arteries promotes plaque stabilization.

Morgan A Schake, Ian S McCue, Evan T Curtis, Thomas J Ripperda, Samuel Harvey, Bryan T Hackfort, Anna Fitzwater, Yiannis S Chatzizisis, Forrest M Kievit, Ryan M Pedrigi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Morgan A SchakeDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Ian S McCueDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Evan T CurtisDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Thomas J RipperdaDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Samuel HarveyDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Bryan T HackfortDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Anna FitzwaterInstitutional Animal Care Program, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Yiannis S ChatzizisisDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Forrest M KievitDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Ryan M PedrigiDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
University of Nebraska–Lincoln · USUniversity of Nebraska Medical Center · US

Funding

ULTRASOUND AS A MECHANOTHERAPY FOR ENDOTHELIAL CELL DYSFUNCTIONR21EB028960 · NIBIB · UNIVERSITY OF NEBRASKA LINCOLN · PI PEDRIGI, RYAN MICHAEL · 2020 to 2020
$603k
NIBIB NIH HHS R21 EB028960
6 · The paper itself

Abstract

Blood flow is a key regulator of atherosclerosis. Disturbed blood flow promotes atherosclerotic plaque development, whereas normal blood flow protects against plaque development. We hypothesized that normal blood flow is also therapeutic, if it were able to be restored within atherosclerotic arteries. Apolipoprotein E-deficient (ApoE

Indexed as

Cardiovascular medicineVascular remodeling

Identifiers

PMID37235059
PMCPMC10206490
OpenAlexW4367043770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.