ArticleOpen forum infectious diseases2023
Enterococci in Diabetic Foot Infections: Prevalence, Clinical Characteristics, and Outcomes.
Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Management of Diabetic Foot Infections Using Phage Therapy.Infection and drug resistance · 2026Review
- Uncovering the Role of Tertiary Lymphoid Organs in the Inflammatory Landscape: A Novel Immunophenotype of Diabetic Foot Ulcers.Journal of cellular and molecular medicine · 2025Article
- Genome-wide analysis ofJournal of bacteriology · 2025Article
- Microbiology of Diabetic Foot Infections in U.S. Veterans.Clinical diabetes : a publication of the American Diabetes Association · 2025Article
- Triple threat: how diabetes results in worsened bacterial infections.Infection and immunity · 2024Review
- A diverse set of Enterococcus-infecting phage provides insight into phage host-range determinants.Virus research · 2024Article
- Microbiological characterization of neuropathic diabetic foot infection: a retrospective study at a Portuguese tertiary hospital.BMC infectious diseases · 2024Article
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Authors and funding
9 authors.
Funding
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Abstract
Background: Diabetic foot infections (DFIs) are frequently polymicrobial, yet the relevance of each isolated pathogen, remains ill-defined. Specifically, the prevalence and pathogenicity of enterococcal DFIs and the impact of targeted antienterococcal treatment remain elusive. Methods: We collected demographic, clinical, and outcome-related data on patients admitted with DFIs to the Hadassah Medical Center diabetic foot unit between 2014 and 2019. The primary outcome was a composite of in-hospital death or major amputation. Secondary outcomes included any amputation, major amputation, length of stay (LOS), and 1-year major amputation or mortality rate. Results: Enterococci were isolated in 35% of 537 eligible DFI case patients, who were notable for a higher prevalence of peripheral vascular disease, increased levels of C-reactive protein, and higher Wagner scores. Infection in enterococci-positive individuals was mostly polymicrobial (96.8% vs 61.0% in non-enterococci-infected patients; Conclusions: Enterococci are common in DFIs and associated with higher rates of amputation and longer hospitalization. A reduction in major amputation rates with appropriate enterococci treatment is suggested retrospectively, meriting validation by future prospective studies.
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