ArticleFrontiers in bioengineering and biotechnology2023
Engineered combinatorial cell device for wound healing and bone regeneration.
Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Rat Calvarial Defect Models in Bone Regeneration Research: A Narrative Review of Critical Size and Micro-Computed Tomography Outcome Reporting.Animals : an open access journal from MDPI · 2026Review
- Advances in nucleic acid delivery strategies for diabetic wound therapy.Journal of clinical & translational endocrinology · 2024Review
- Ultrasound-mediated spatial and temporal control of engineered cells in vivo.Nature communications · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth factors are the key regulators that promote tissue regeneration and healing processes. While the effects of individual growth factors are well documented, a combination of multiple secreted growth factors underlies stem cell-mediated regeneration. To avoid the potential dangers and labor-intensive individual approach of stem cell therapy while maintaining their regeneration-promoting effects based on multiple secreted growth factors, we engineered a "mix-and-match" combinatorial platform based on a library of cell lines producing growth factors. Treatment with a combination of growth factors secreted by engineered mammalian cells was more efficient than with individual growth factors or even stem cell-conditioned medium in a gap closure assay. Furthermore, we implemented in a mouse model a device for allogenic cell therapy for an
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