ReviewCureus2023
Aminotransferases in Relation to the Severity of Dengue: A Systematic Review.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Clinical and Epidemiological Profile of Liver Dysfunction in Dengue Fever - A Cross-Sectional Study.Journal of pharmacy & bioallied sciences · 2026Article
- Evaluation of immune-endothelial activation markers for the differentiation of severe dengue.Journal of translational medicine · 2025Article
- Role of biomarkers in predicting mortality in patients with flaviviral disease endemic to South India: a retrospective observational study.BMC infectious diseases · 2025Observational
- Machine Learning Nomogram for Predicting Dengue Shock Syndrome in Pediatric Patients With Dengue Fever in Vietnam.Cureus · 2025Article
- Hemobilia: A Narrative Review of Current Diagnostic Techniques and Emerging Management Strategies.Cureus · 2024Review
- Review
- Review
- The Role of Microbiome in Cardiovascular Health: Insights for Primary Care Interventions.Cureus · 2024Review
- Exploring Aspirin's Potential in Cancer Prevention: A Comprehensive Review of the Current Evidence.Cureus · 2024Review
- The Genetic Diagnostics of Hemochromatosis: Disparities in Low- Versus High-Income Countries.Cureus · 2024Review
- Inflammatory Bowel Disease and Cardiovascular Disease: An Integrative Review With a Focus on the Gut Microbiome.Cureus · 2024Review
- Article
- Simultaneous Dengue and Chikungunya Coinfection in Endemic Area in Brazil: Clinical Presentation and Implications for Public Health.Research square · 2024Article
- Clinical, Hematological, and Biochemical Profile in Seropositive Dengue Cases at a Tertiary Care Hospital in Nepal.Journal of tropical medicine · 2024Article
- Transaminitis among Patients with Dengue Fever Visiting a Tertiary Care Centre.JNMA; journal of the Nepal Medical Association · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A systematic review was conducted to investigate the relationship between aminotransferases and the severity of dengue infection, which is a prevalent and significant infection in tropical and subtropical regions. Aminotransferases are enzymes that are often elevated in dengue due to the liver's physiological and immunological response to the infection. This review focused on analyzing various studies that examined the correlation between aminotransferase levels and the severity of dengue. Extensive literature searches were performed using ("dengue*" OR "dengue fever*" OR "dengue haemorrhagic fever*" OR "dengue shock syndrome*") AND ("alanine aminotransferase*" OR "aspartate aminotransferase*") on PubMed. The selected articles were thoroughly reviewed, encompassing epidemiology, pathogenesis, and clinical manifestations of dengue. The consistent findings across the studies indicated that aminotransferases can serve as predictive markers for dengue severity. Therefore, early assessment of liver enzyme levels is crucial in dengue cases, and elevated levels should be closely monitored to prevent adverse outcomes.
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Registered trials
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