Evidence map›Paper›PMID 37234388›Full record

ArticleFujita medical journal2023

Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction.

Yusuke Funato, Yuki Higashimoto, Yoshiki Kawamura, Yoshiko Sakabe, Minori Iwakura, Masaru Ihira, Kazuya Shiogama, Masafumi Miyata, Haruki Nishizawa, Takao Sekiya and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fujita medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yusuke FunatoDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Yuki HigashimotoFaculty of Medical Technology, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Yoshiki KawamuraDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Yoshiko SakabeDepartment of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Minori IwakuraFaculty of Medical Technology, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Masaru IhiraFaculty of Clinical Engineering, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Kazuya ShiogamaFaculty of Pathology, Fujita Health University, School of Medical Sciences, Toyoake, Aichi, Japan.
Masafumi MiyataDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Haruki NishizawaDepartment of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Takao SekiyaDepartment of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Takuma FujiiDepartment of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Isao KosugiDepartment of Regenerative and Infectious Pathology, Hamamatsu University, School of Medicine, Hamamatsu, Shizuoka, Japan.
Tetsushi YoshikawaDepartment of Pediatrics, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Fetal human cytomegalovirus (HCMV) infection might be involved in fetal growth restriction (FGR). Maternal serostatus and the prevalence of congenital HCMV infection are affected by various factors, such as socioeconomic status and ethnicity. Therefore, the prevalence of congenital HCMV-related FGR should be examined in each region. Methods: Seventy-eight cases of FGR with delivery between January 2012 and January 2017 at Fujita Health University Hospital were studied. Twenty-one non-FGR cases were also included as a control group. Placental sections obtained from the FGR and control cases were immunostained with two primary antibodies for detecting immediate early antigens. Results: Nineteen placental samples from FGR cases with another etiology were excluded. Finally, 59 placental samples from FGR cases of unknown etiology were included in the pathological analysis. Four of 59 (6.8%) placental samples were positive for HCMV antigen. All four positive cases were stained with the M0854 antibody, and there were no positive case with the MAB810R antibody. Neither maternal nor infantile clinical features were different between the HCMV-positive and -negative FGR cases. A pathological examination showed a hematoma in three of four cases and infarction in two of four cases. Conclusions: HCMV antigen was detected in 6.8% of placental samples obtained from FGR cases without an obvious etiology. No remarkable maternal or neonatal clinical features discriminated HCMV-related FGR from FGR due to other causes. Vasculitis and inflammation might play important roles in the pathogenesis of HCMV-related FGR.

Indexed as

Congenital infectionGrowth restrictionHuman cytomegalovirusImmunohistochemistryPlacenta

Identifiers

PMID37234388
PMCPMC10206905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.