Evidence map›Paper›PMID 37234369›Full record

ArticleFrontiers in cardiovascular medicine2023

Current status of transcatheter mitral valve replacement: systematic review and meta-analysis.

Alberto Alperi, Pablo Avanzas, Victor Leon, Iria Silva, Daniel Hernández-Vaquero, Marcel Almendárez, Rut Álvarez, Félix Fernández, Cesar Moris, Isaac Pascual

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alberto AlperiDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Pablo AvanzasDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Victor LeonDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Iria SilvaDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Daniel Hernández-VaqueroDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Marcel AlmendárezDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Rut ÁlvarezDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Félix FernándezDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Cesar MorisDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.
Isaac PascualDepartment of Cardiology, Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Mitral Regurgitation (MR) has a strong impact on quality of life and on mid-term survival. Transcatheter mitral valve replacement (TMVR) is rapidly expanding and a growing number of studies have been published recently. Methods: A systematic review of studies reporting on clinical data for patients with symptomatic severe MR undergoing TMVR was performed. Early- and mid-term outcomes (clinical and echocardiographic) were evaluated. Overall weighted means and rates were calculated. Risk ratios or mean differences were calculated for pre- and post-procedural comparisons. Results: A total of 12 studies and 347 patients who underwent TMVR with devices clinically available or under clinical evaluation were included. Thirty-day mortality, stroke and major bleeding rates were 8.4%, 2.6%, and 15.6%, respectively. Pooled random-effects demonstrated a significant reduction of ≥ grade 3+ MR (RR: 0.05; 95% CI: 0.02-0.11; Conclusions: Among 12 studies and 347 patients comprising the updated evidence with current TMVR systems there was a statistically significant reduction in ≥ grade 3+ MR and in the number of patients exhibiting poor functional class (NYHA 3 or 4) after the intervention. Overall rate of major bleeding was the main shortcoming of this technique.

Indexed as

mitral incompetencemitral insufficiencymitral regurgitationmitral valvetranscatheter mitral valve replacement

Identifiers

PMID37234369
PMCPMC10206247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.