ArticleJACS Au2023
Rapid Synthesis of β-Chiral Sulfones by Ni-Organophotocatalyzed Enantioselective Sulfonylalkenylation of Alkenes.
Article in JACS Au, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 40 citations in OpenAlex.
- Photocatalytic multicomponent alkene dicarbofunctionalizationChemical science · 2026Article
- Article
- CoH-catalyzed asymmetric remote hydroalkylation of heterocyclic alkenes: a rapid approach to chiral five-membered S- and O-heterocycles.Chemical science · 2024Article
- Enantioselective C(spAccounts of chemical research · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
β-Chiral sulfones are substructures widespread in drug molecules and bioactive targets and serve as important chiral synthons in organic synthesis yet are challenging to access. Herein, a three-component strategy enabled by visible-light- and Ni-catalyzed sulfonylalkenylation of styrenes for the synthesis of enantioenriched β-chiral sulfones has been developed. This dual-catalysis strategy allows for one-step skeletal assembly along with the control of enantioselectivity in the presence of a chiral ligand, providing an efficient and straightforward access to enantioenriched β-alkenyl sulfones from easily available and simple starting materials. Mechanistic investigations reveal that the reaction undergoes a chemoselective radical addition over two alkenes followed by a Ni-intercepted asymmetric C
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