Evidence map›Paper›PMID 37233989›Full record

SynthesisEpigenetics2023

Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis.

Amena Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M Masachs, Jordana T Bell, Rory Wilson, Barbara Thorand and 24 more

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  4. Article
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  9. Article
  10. Review
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  12. Diet as an epigenetic factor in inflammatory bowel disease.World journal of gastroenterology · 2023
    Review
  13. The Nutriepigenome.Genes · 2023
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 16 institutions in 9 countries.

Amena KeshawarzFramingham Heart Study, Framingham, Framingham, MA, USA.ORCID 0000-0002-4645-2411
Roby JoehanesFramingham Heart Study, Framingham, Framingham, MA, USA.
Jiantao MaFramingham Heart Study, Framingham, Framingham, MA, USA.
Gha Young LeeFramingham Heart Study, Framingham, Framingham, MA, USA.
Ricardo CosteiraDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Pei-Chien TsaiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0003-1575-9020
Olatz M MasachsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Rory WilsonResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg, Germany.
Barbara ThorandInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany.
Juliane WinkelmannInstitute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany.
Jakob LinseisenChair of Epidemiology, University Augsburg at University Hospital Augsburg, Augsburg, Germany.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg, Germany.
Terho LehtimäkiDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Pashupati P MishraDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Mika KähönenFinnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Mika HelminenTays Research Services, Tampere University Hospital, Tampere, Finland.
Carol A WangSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia.
Phillip E MeltonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Rae-Chi HuangNutrition & Health Innovation Research Institute, Edith Cowan University, Perth, Australia.
Craig E PennellFaculty of Social Sciences, Health Sciences, Tampere University, Tampere, Finland.
Therese A O'SullivanSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.
Carolina Ochoa-RosalesDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Trudy VoortmanDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Kristin L YoungDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Hebrew Senior Life, Chapel Hill, North Carolina, USA.
Misa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Hebrew Senior Life, Chapel Hill, North Carolina, USA.
Yujie WangDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Hebrew Senior Life, Chapel Hill, North Carolina, USA.
Douglas P KielDepartment of Medicine, Beth Israel Deaconess Medical Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Caren E SmithJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Paul F JacquesFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Daniel LevyFramingham Heart Study, Framingham, Framingham, MA, USA.ORCID 0000-0003-1843-8724
Helmholtz Zentrum München · DETampere University · FIKing's College London · GBNational Institutes of Health · USTufts University · USUniversity of North Carolina at Chapel Hill · USEdith Cowan University · AUErasmus MC · NLAdolfo Ibáñez University · CLBeth Israel Deaconess Medical Center · USChang Gung University · TWFramingham Heart Study · USHunter Medical Research Institute · AUUniversity Hospital Augsburg · DEUniversity of Tasmania · AUUniversity of Turku · FI

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and BloodR01HL087641 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2006 to 2008
$3.7M
GWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6M
COMMUNITY AND COHORT SURVEILLANCE PROGRAMS-N01HC55015N01HC055015 · HC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CHAMBLESS, LLOYD E · 1985 to 2006
$1.1M
COMMUNITY AND COHORT SURVEILLANCE PROGRAMN01HC055016 · HC · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE M · 1985 to 2000
$785k
FIELD CENTER FOR CCSPN01HC055019 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1985 to 2000
$748k
Dietary factors, biomarkers, metabolic pathways related to non-alcoholic fatty liver diseaseK22HL135075 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MA, JIANTAO · 2019 to 2021
$747k
Biotechnology and Biological Sciences Research Council BB/S020845/1Biotechnology and Biological Sciences Research Council BB/T019980/1NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS K22 HL135075NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R21 HL140419NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273Wellcome Trust
6 · The paper itself

Abstract

backgroundDietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns.

methodsWe meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association between self-reported dietary and supplemental intake of vitamins C and E with DNA methylation. EWAS were adjusted for age, sex, BMI, caloric intake, blood cell type proportion, smoking status, alcohol consumption, and technical covariates. Significant results of the meta-analysis were subsequently evaluated in gene set enrichment analysis (GSEA) and expression quantitative trait methylation (eQTM) analysis.

resultsIn meta-analysis, methylation at 4,656 CpG sites was significantly associated with vitamin C intake at FDR ≤ 0.05. The most significant CpG sites associated with vitamin C (at FDR ≤ 0.01) were enriched for pathways associated with systems development and cell signalling in GSEA, and were associated with downstream expression of genes enriched in the immune response in eQTM analysis. Furthermore, methylation at 160 CpG sites was significantly associated with vitamin E intake at FDR ≤ 0.05, but GSEA and eQTM analysis of the top most significant CpG sites associated with vitamin E did not identify significant enrichment of any biological pathways investigated.

conclusionsWe identified significant associations of many CpG sites with vitamin C and E intake, and our results suggest that vitamin C intake may be associated with systems development and the immune response.

Indexed as

Ascorbic AcidDNA MethylationCpG IslandsEpigenesis, GeneticEpigenomeGenome-Wide Association StudyHumansVitamin EVitaminsAscorbic AcidVitamin EVitaminsdietepidemiologyEpigeneticsVitamin CVitamin E

Identifiers

PMID37233989
PMCPMC10228397
OpenAlexW4378349483

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.