Evidence map›Paper›PMID 37233699›Full record

ArticleMetabolites2023

Computational Insights into Natural Antischistosomal Metabolites as SmHDAC8 Inhibitors: Molecular Docking, ADMET Profiling, and Molecular Dynamics Simulation.

Abdulrahim A Alzain, Rua M Mukhtar, Nihal Abdelmoniem, Fatima A Elbadwi, Amira Hussien, Elrashied A E Garelnabi, Wadah Osman, Asmaa E Sherif, Amgad I M Khedr, Kholoud F Ghazawi and 4 more

Abstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Computer-Aided Discovery ofBiomedical engineering and computational biology · 2024
    Article
  7. Computer-Assisted Discovery ofBioinformatics and biology insights · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abdulrahim A AlzainDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.ORCID 0000-0001-8695-6852
Rua M MukhtarDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Nihal AbdelmoniemDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Fatima A ElbadwiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.ORCID 0000-0001-9276-0311
Amira HussienDepartment of Pharmacology, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Elrashied A E GarelnabiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Al-Qasr Ave, Khartoum 11111, Sudan.
Wadah OsmanDepartment of Pharmacognosy, Faculty of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Asmaa E SherifDepartment of Pharmacognosy, Faculty of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Amgad I M KhedrDepartment of Pharmacognosy, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.ORCID 0000-0002-7658-4618
Kholoud F GhazawiClinical Pharmacy Department, College of Pharmacy, Umm Al-Qura University, Makkah 24382, Saudi Arabia.
Waad A SammanDepartment of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah 30078, Saudi Arabia.
Sabrin R M IbrahimPreparatory Year Program, Department of Chemistry, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
Gamal A MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ahmed AshourDepartment of Pharmacognosy, Faculty of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.ORCID 0000-0003-4081-0369

Funding

This study is supported via funding from Prince Sattam bin Abdulaziz University. Project number (PSAU/2023/R/1444). PSAU/2023/R/1444
6 · The paper itself

Abstract

Schistosomiasis is a neglected tropical disease with a significant socioeconomic impact. It is caused by several species of blood trematodes from the genus

Indexed as

allostericdrug discoveryhealth and wellbeingmolecular dockingmolecular dynamicsphytochemicalsschistosomiasisSmHDAC8

Identifiers

PMID37233699
PMCPMC10221329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.