Evidence map›Paper›PMID 37233679›Full record

ArticleMetabolites2023

Repeated Low-Level Blast Exposure Alters Urinary and Serum Metabolites.

Austin Sigler, Jiandong Wu, Annalise Pfaff, Olajide Adetunji, Paul Nam, Donald James, Casey Burton, Honglan Shi

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07652021 (A Randomized Controlled Trial Comparing Healing Outcomes of Intralesional Glucantime With and Without Fractional CO₂ Laser in Adults With Cutaneous Leishmaniasis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07652021 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized Controlled Trial Comparing Healing Outcomes of Intralesional Glucantime With and Without Fractional CO₂ Laser in Adults With Cutaneous Leishmaniasis

TypeinterventionalSponsorCombined military hospital PeshawarRan2026 to 2027Enrolled150ConditionsCutaneous LeishminiasisArmsMeglumine Antimoniate, Fractional CO₂ laser
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Austin SiglerDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.
Jiandong WuDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.ORCID 0000-0002-4818-4609
Annalise PfaffDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.
Olajide AdetunjiDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.
Paul NamDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.
Donald JamesPhelps Health, Rolla, MO 65401, USA.
Casey BurtonDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.ORCID 0000-0002-0729-6743
Honglan ShiDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA.
Missouri University of Science and Technology · USPhelps County Regional Medical Center · US

Funding

United States Army Research Laboratory W911NF-14-2-0034
6 · The paper itself

Abstract

Repeated exposure to low-level blast overpressures can produce biological changes and clinical sequelae that resemble mild traumatic brain injury (TBI). While recent efforts have revealed several protein biomarkers for axonal injury during repetitive blast exposure, this study aims to explore potential small molecule biomarkers of brain injury during repeated blast exposure. This study evaluated a panel of ten small molecule metabolites involved in neurotransmission, oxidative stress, and energy metabolism in the urine and serum of military personnel (

Indexed as

biomarkersblast exposurehomovanillic acid

Identifiers

PMID37233679
PMCPMC10222206
OpenAlexW4375950126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.