Evidence map›Paper›PMID 37233663›Full record

ArticleMetabolites2023

Donkey Colostrum and Milk: How Dietary Probiotics Can Affect Metabolomic Profile, Alkaline Sphingomyelinase and Alkaline Phosphatase Activity.

Fulvio Laus, Luca Laghi, Marilena Bazzano, Maria Grazia Cifone, Benedetta Cinque, Yaosen Yang, Andrea Marchegiani

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Targeted metabolomics of organic and amino acids in giraffe milk during mid- to late-lactation.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  2. Article
  3. Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  4. Article
  5. Article
  6. Unraveling the genetic and physiological potential of donkeys: insights from genomics, proteomics, and metabolomics approaches.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  7. Article
  8. Abdominal Ultrasonography in Healthy Female Standard Donkeys.Animals : an open access journal from MDPI · 2025
    Article
  9. Article
  10. Review
  11. Animals : an open access journal from MDPI · 2024
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fulvio LausSchool of Biosciences and Veterinary Medicine, University of Camerino, 62024 Matelica, Italy.ORCID 0000-0001-6331-6684
Luca LaghiCentre of Foodomics, Department of Agro-Food Science and Technology, University of Bologna, 47521 Cesena, Italy.ORCID 0000-0003-1593-7376
Marilena BazzanoSchool of Biosciences and Veterinary Medicine, University of Camerino, 62024 Matelica, Italy.
Maria Grazia CifoneDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-9923-5445
Benedetta CinqueDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Yaosen YangSchool of Biosciences and Veterinary Medicine, University of Camerino, 62024 Matelica, Italy.
Andrea MarchegianiSchool of Biosciences and Veterinary Medicine, University of Camerino, 62024 Matelica, Italy.ORCID 0000-0002-3629-0391
Università di Camerino · ITUniversity of L'Aquila · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positive results on animal health, feed efficiency, and milk's nutritional content have been obtained after oral administration of probiotics. The aim of the present study was therefore to evaluate the effect of dietary supplementation with high numbers of multispecies probiotic formulations on the milk metabolomic profiles of alkaline sphingomyelinase (alk-SMase) and alkaline phosphatase (ALP) in donkeys. Twenty animals were randomly allocated to receive either a normal diet (group B) or a supplemented diet (group A). Colostrum and milk samples were obtained within 48 h, at 15 days (supplementation start), and at 45 days after parturition. Different metabolomic profiles were observed between colostrum and milk, as were the concentrations of 12 metabolites that changed following 30 days of probiotic supplementation. Alk-SMase activity was found to be higher in donkey colostrum (vs. milk at 15 days); this enzyme, together with ALP, increased in milk after 30 days of probiotic supplementation. The results of the present study provide new insight into the complex changes in donkey colostrum and milk composition in the first 45 days of lactation and how the milk metabolome can be modulated by probiotic supplementation.

Indexed as

donkey milkmetabolomic analysisprobiotics

Identifiers

PMID37233663
PMCPMC10223555
OpenAlexW4367624417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.