ReviewMembranes2023
The Potassium Efflux System Kef: Bacterial Protection against Toxic Electrophilic Compounds.
Review in Membranes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Idiomarina solivarensis sp. nov., halophilic bacterium isolated from brine of the former subsurface salt mine in Solivar (Slovakia) showing a unique fatty acids profile.Archives of microbiology · 2026Article
- Bacterial Adaptation to Stress Induced by Glyoxal/Methylglyoxal and Advanced Glycation End Products.Microorganisms · 2025Review
- Genomic diversity and global distribution of four new prasinoviruses from the tropical north Pacific.Microbiology spectrum · 2025Article
- Genomic and functional analyses reveal Pseudomonas granadensis CT364 is a plant growth-promoting endophyte.BMC microbiology · 2025Article
- Comparative genomic analysis and characterization of novel high-quality draft genomes from the coal metagenome.World journal of microbiology & biotechnology · 2024Article
- Regulation of potassium uptake inJournal of bacteriology · 2024Article
- Structure and mechanism of the KNature communications · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kef couples the potassium efflux with proton influx in gram-negative bacteria. The resulting acidification of the cytosol efficiently prevents the killing of the bacteria by reactive electrophilic compounds. While other degradation pathways for electrophiles exist, Kef is a short-term response that is crucial for survival. It requires tight regulation since its activation comes with the burden of disturbed homeostasis. Electrophiles, entering the cell, react spontaneously or catalytically with glutathione, which is present at high concentrations in the cytosol. The resulting glutathione conjugates bind to the cytosolic regulatory domain of Kef and trigger activation while the binding of glutathione keeps the system closed. Furthermore, nucleotides can bind to this domain for stabilization or inhibition. The binding of an additional ancillary subunit, called KefF or KefG, to the cytosolic domain is required for full activation. The regulatory domain is termed K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.