Evidence map›Paper›PMID 37233502›Full record

ReviewMarine drugs2023

Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation.

Susana P Gaudêncio, Engin Bayram, Lada Lukić Bilela, Mercedes Cueto, Ana R Díaz-Marrero, Berat Z Haznedaroglu, Carlos Jimenez, Manolis Mandalakis, Florbela Pereira, Fernando Reyes and 1 more

Abstract readReview
In one paragraph

Review in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. The Oxytetracycline ProducerInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Phytochemical Characterization of Freeze-DriedMolecules (Basel, Switzerland) · 2026
    Article
  4. Phytochemistry and Pharmacological Potential of the GenusPharmaceuticals (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Susana P GaudêncioAssociate Laboratory i4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.ORCID 0000-0002-5510-1170
Engin BayramInstitute of Environmental Sciences, Room HKC-202, Hisar Campus, Bogazici University, Bebek, Istanbul 34342, Turkey.
Lada Lukić BilelaDepartment of Biology, Faculty of Science, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.ORCID 0000-0001-7423-6284
Mercedes CuetoInstituto de Productos Naturales y Agrobiología-CSIC, 38206 La Laguna, Spain.ORCID 0000-0002-9112-6877
Ana R Díaz-MarreroInstituto de Productos Naturales y Agrobiología-CSIC, 38206 La Laguna, Spain.ORCID 0000-0002-8886-7519
Berat Z HaznedarogluInstitute of Environmental Sciences, Room HKC-202, Hisar Campus, Bogazici University, Bebek, Istanbul 34342, Turkey.ORCID 0000-0002-0081-8801
Carlos JimenezCICA- Centro Interdisciplinar de Química e Bioloxía, Departamento de Química, Facultade de Ciencias, Universidade da Coruña, 15071 A Coruña, Spain.ORCID 0000-0003-2628-303X
Manolis MandalakisInstitute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, HCMR Thalassocosmos, 71500 Gournes, Crete, Greece.ORCID 0000-0002-7469-4290
Florbela PereiraLAQV, REQUIMTE, Chemistry Department, NOVA School of Science and Technology, NOVA University of Lisbon, 2819-516 Caparica, Portugal.ORCID 0000-0003-4392-4644
Fernando ReyesFundación MEDINA, Avda. del Conocimiento 34, 18016 Armilla, Spain.ORCID 0000-0003-1607-5106
Deniz TasdemirGEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany.ORCID 0000-0002-7841-6271

Funding

European Commission COST Action CA18238
6 · The paper itself

Abstract

Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known compounds) and structure elucidation, particularly the determination of the absolute configuration of metabolites with stereogenic centers. This review comprehensively focuses on recent technological and instrumental advances, highlighting the development of methods that alleviate these obstacles, paving the way for accelerating NP discovery towards biotechnological applications. Herein, we emphasize the most innovative high-throughput tools and methods for advancing bioactivity screening, NP chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, and three-dimensional NP structure elucidation.

Indexed as

Biological ProductsComputational BiologyDatabases, FactualGenomicsMetabolomicsBiological Productsblue biotechnologycomputer assisted structure elucidation (CASE)dereplicationGlobal Natural Product Social Molecular Networking (GNPS)high throughput next-generation sequencing (HT/NGS)high-throughput screening (HTS)informatic chemometricsmode of action (MoA)molecular networkingnatural productsnatural products databasesrelative and absolute configuration determination in structure elucidation

Identifiers

PMID37233502
PMCPMC10222211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.