Evidence map›Paper›PMID 37233477›Full record

ReviewMarine drugs2023

A Bibliometric and In Silico-Based Analysis of Anti-Lung Cancer Compounds from Sea Cucumber.

Afshin Zare, Safoura Izanloo, Sajed Khaledi, Mussin Nadiar Maratovich, Asset Askerovich Kaliyev, Nurgul Abdullayevna Abenova, Farhad Rahmanifar, Mahdi Mahdipour, Shabnam Bakhshalizadeh, Reza Shirazi and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Afshin ZareThe PerciaVista Biotechnology Company, Shiraz 71676-83745, Iran.ORCID 0000-0002-1932-8773
Safoura IzanlooDepartment of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
Sajed KhalediDepartment of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14117-13116, Iran.ORCID 0009-0008-1987-1208
Mussin Nadiar MaratovichGeneral Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan.ORCID 0000-0003-3600-8840
Asset Askerovich KaliyevGeneral Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan.
Nurgul Abdullayevna AbenovaDepartment of Internal Diseases, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan.ORCID 0000-0003-0395-9025
Farhad RahmanifarDepartment of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz 71348-14336, Iran.
Mahdi MahdipourStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz 51666-53431, Iran.ORCID 0000-0002-2729-4593
Shabnam BakhshalizadehReproductive Development, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.ORCID 0000-0003-1920-9093
Reza ShiraziDepartment of Anatomy, School of Medical Sciences, Biomedical & Health, UNSW Sydney, Sydney, NSW 1466, Australia.ORCID 0000-0002-3907-079X
Nader TanidehThe PerciaVista Biotechnology Company, Shiraz 71676-83745, Iran.ORCID 0000-0001-9282-1778
Amin TamadonThe PerciaVista Biotechnology Company, Shiraz 71676-83745, Iran.ORCID 0000-0002-0222-3035
West Kazakhstan Marat Ospanov State Medical University · KZIran University of Medical Sciences · IRShiraz University · IRShiraz University of Medical Sciences · IRTabriz University of Medical Sciences · IRTarbiat Modares University · IRThe University of Melbourne · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is one of the most lethal malignancies in the world. However, current curative approaches for treating this type of cancer have some weaknesses. Therefore, scientists are attempting to discover new anti-lung cancer agents. Sea cucumber is a marine-derived source for discovering biologically active compounds with anti-lung cancer properties. To explore the anti-lung cancer properties of sea cucumber, we analyzed surveys using VOSviewer software and identified the most frequently used keywords. We then searched the Google Scholar database for compounds with anti-lung cancer properties within that keyword family. Finally, we used AutoDock 4 to identify the compounds with the highest affinity for apoptotic receptors in lung cancer cells. The results showed that triterpene glucosides were the most frequently identified compounds in studies examining the anti-cancer properties of sea cucumbers. Intercedenside C, Scabraside A, and Scabraside B were the three triterpene glycosides with the highest affinity for apoptotic receptors in lung cancer cells. To the best of our knowledge, this is the first time that anti-lung cancer properties of sea cucumber-derived compounds have been examined in in silico conditions. Ultimately, these three components displayed anti-lung cancer properties in in silico conditions and may be used for the manufacture of anti-lung cancer agents in the near future.

Indexed as

Antineoplastic AgentsLung NeoplasmsSea CucumbersTriterpenesAnimalsBibliometricsGlycosidesHumansMolecular StructureAntineoplastic AgentsGlycosidesTriterpenesanti-cancer agentsapoptosisbibliometricsglucosidesin silico techniqueslung neoplasmsmarine biologysea cucumberstriterpenes

Identifiers

PMID37233477
PMCPMC10223633
OpenAlexW4367311653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.