Evidence map›Paper›PMID 37233458›Full record

ArticleMarine drugs2023

SPR Sensor-Based Analysis of the Inhibition of Marine Sulfated Glycans on Interactions between Monkeypox Virus Proteins and Glycosaminoglycans.

Peng He, Deling Shi, Yunran Li, Ke Xia, Seon Beom Kim, Rohini Dwivedi, Marwa Farrag, Vitor H Pomin, Robert J Linhardt, Jonathan S Dordick and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  13. Mpox (formerly monkeypox): pathogenesis, prevention, and treatment.Signal transduction and targeted therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Peng HeCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.ORCID 0000-0002-7549-1890
Deling ShiCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Yunran LiCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Ke XiaCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.ORCID 0000-0001-9699-9901
Seon Beom KimDepartment of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, The University of Mississippi, Oxford, MS 38677, USA.ORCID 0000-0001-8015-1404
Rohini DwivediDepartment of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, The University of Mississippi, Oxford, MS 38677, USA.
Marwa FarragDepartment of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, The University of Mississippi, Oxford, MS 38677, USA.ORCID 0000-0001-7104-3815
Vitor H PominDepartment of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, The University of Mississippi, Oxford, MS 38677, USA.ORCID 0000-0002-5015-8880
Robert J LinhardtCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.ORCID 0000-0003-2219-5833
Jonathan S DordickCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Fuming ZhangCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.ORCID 0000-0003-2803-3704
Rensselaer Polytechnic Institute · USUniversity of Mississippi · US

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Glycomics-driven diagnostics for Candida aurisR21AI156573 · NIAID · RENSSELAER POLYTECHNIC INSTITUTE · PI CHATURVEDI, VISHNU, ZHANG, FUMING · 2021 to 2022
$454k
Biacore T200 Surface Plasmon Resonance SpectroscopyS10OD028523 · OD · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J · 2020 to 2020
$344k
Disruption of CS/KSPG-Mediated Neuronal Outgrowth InhibitionR03NS110996 · NINDS · UNIVERSITY OF MISSISSIPPI · PI POMIN, VITOR HUGO · 2020 to 2020
$142k
NIAID NIH HHS R21 AI156573NIGMS NIH HHS P20 GM130460NIH HHS 1P20GM130460-01A1-7936, and 1R03NS110996-01A1, S10OD028523, R21AI156573NIH HHS S10 OD028523NINDS NIH HHS R03 NS110996
6 · The paper itself

Abstract

Sulfated glycans from marine organisms are excellent sources of naturally occurring glycosaminoglycan (GAG) mimetics that demonstrate therapeutic activities, such as antiviral/microbial infection, anticoagulant, anticancer, and anti-inflammation activities. Many viruses use the heparan sulfate (HS) GAG on the surface of host cells as co-receptors for attachment and initiating cell entry. Therefore, virion-HS interactions have been targeted to develop broad-spectrum antiviral therapeutics. Here we report the potential anti-monkeypox virus (MPXV) activities of eight defined marine sulfated glycans, three fucosylated chondroitin sulfates, and three sulfated fucans extracted from the sea cucumber species

Indexed as

GlycosaminoglycansMonkeypox virusSea CucumbersAnimalsAntiviral AgentsChondroitin SulfatesHeparan SulfateHeparinSulfatesSurface Plasmon ResonanceAntiviral AgentsChondroitin SulfatesGlycosaminoglycansHeparan SulfateHeparinSulfatesheparinmarine sulfated glycansmonkeypox virusprotein A29protein A35sea cucumberssurface plasmon resonance

Identifiers

PMID37233458
PMCPMC10222398
OpenAlexW4366987289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.