Evidence map›Paper›PMID 37233457›Full record

ArticleMarine drugs2023

Optimization of Extraction of Phlorotannins from the Arctic

Ekaterina D Obluchinskaya, Olga N Pozharitskaya, Vadim A Shevyrin, Elena G Kovaleva, Elena V Flisyuk, Alexander N Shikov

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 86 citations in OpenAlex.

  1. Review
  2. Review
  3. Enzymatic Hydrolysates fromMarine drugs · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Sustainable Recovery of Phlorotannins fromAntioxidants (Basel, Switzerland) · 2025
    Article
  12. Foods (Basel, Switzerland) · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Exploring Phenolic Compounds Extraction from Saffron (Molecules (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ekaterina D ObluchinskayaResearch Group of Biochemistry and Technology of Hydrobionts of Algae and Invertebrates, Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), 17 Vladimirskaya Str., 183010 Murmansk, Russia.ORCID 0000-0003-4456-656X
Olga N PozharitskayaResearch Group of Biochemistry and Technology of Hydrobionts of Algae and Invertebrates, Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), 17 Vladimirskaya Str., 183010 Murmansk, Russia.ORCID 0000-0003-1061-0665
Vadim A ShevyrinScientific, Educational and Innovation Center of Chemical and Pharmaceutical Technologies, Ural Federal University Named after the First President of Russia B. N. Yeltsin (UrFU), 19 Mira Str., 620002 Ekaterinburg, Russia.ORCID 0000-0002-0369-0786
Elena G KovalevaScientific, Educational and Innovation Center of Chemical and Pharmaceutical Technologies, Ural Federal University Named after the First President of Russia B. N. Yeltsin (UrFU), 19 Mira Str., 620002 Ekaterinburg, Russia.
Elena V FlisyukDepartment of Technology of Pharmaceutical Formulations, St. Petersburg State Chemical Pharmaceutical University, 14a Prof. Popov Str., 197376 Saint Petersburg, Russia.
Alexander N ShikovResearch Group of Biochemistry and Technology of Hydrobionts of Algae and Invertebrates, Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), 17 Vladimirskaya Str., 183010 Murmansk, Russia.ORCID 0000-0003-4351-0695
Murmansk Marine Biological Institute · RUUral Federal University · RUSaint - Petersburg State Chemical Pharmaceutical Academy · RU

Funding

Ministry of Science and Higher Education of the Russian Federation within the framework of the Government Assignment to the Murmansk Marine Biological Institute Russian Academy of Sciences State Reg. No. 121091600104-7Russian Science Foundation 20-66-47017
6 · The paper itself

Abstract

Phlorotannins are secondary metabolites produced mainly by brown seaweeds (Phaeophyceae) and belong to the class of polyphenolic compounds with diverse bioactivities. The key factors in the extraction of polyphenols are the selection of a suitable solvent, method of extraction and selection of optimal conditions. Ultrasonic-assisted extraction (UAE) is one of the advanced energy-saving methods suitable for the extraction of labile compounds. Methanol, acetone, ethanol and ethyl acetate are the most commonly used solvents for polyphenol extraction. As alternatives to toxic organic solvents, a new class of green solvents, natural deep eutectic solvents (NADES), has been proposed for the efficient extraction of a wide range of natural compounds including polyphenols. Several NADES were screened previously for the extraction of phlorotannins; however, the extraction conditions were not optimized and chemical profiling of NADES extract was not performed. The purpose of this work was to study the effect of selected extraction parameters on the phlorotannin content in NADES extract from

Indexed as

FucusTandem Mass SpectrometryChromatography, High Pressure LiquidDeep Eutectic SolventsPlant ExtractsSolventsDeep Eutectic SolventsPlant ExtractsSolventsalgaArcticextractionFucus vesiculosusNADESnatural deep eutectic solventphlorotanninsresponse surface methodology (RSM)seaweed

Identifiers

PMID37233457
PMCPMC10223229
OpenAlexW4366828747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.