Evidence map›Paper›PMID 37233275›Full record

ReviewJournal of fungi (Basel, Switzerland)2023

Fungal Drug Response and Antimicrobial Resistance.

Paloma Osset-Trénor, Amparo Pascual-Ahuir, Markus Proft

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Drug susceptibility ofIranian journal of microbiology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. An optimized protocol forbioRxiv : the preprint server for biology · 2025
    Article
  10. Biotherapeutic Potential of Probiotic YeastIndian journal of microbiology · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Antifungal activity of guanidine compounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Evaluation of Antifungal Activity AgainstHIV/AIDS (Auckland, N.Z.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Paloma Osset-TrénorDepartment of Biotechnology, Instituto de Biología Molecular y Celular de Plantas IBMCP, Universidad Politécnica de Valencia, 46022 Valencia, Spain.
Amparo Pascual-AhuirDepartment of Biotechnology, Instituto de Biología Molecular y Celular de Plantas IBMCP, Universidad Politécnica de Valencia, 46022 Valencia, Spain.
Markus ProftDepartment of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia IBV-CSIC, Consejo Superior de Investigaciones Científicas CSIC, 46010 Valencia, Spain.ORCID 0000-0002-6788-5830
Instituto de Biología Molecular y Celular de Plantas · ESConsejo Superior de Investigaciones Científicas · ES

Funding

Agencia Valenciana de la Innovación INNEST/2021/266Ministerio de Ciencia, Innovación y Universidades PID2019-104214RB-I00
6 · The paper itself

Abstract

Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals. The limited number of antifungal agents and the emergence of resistance have led to a critical need to understand the mechanisms of antifungal drug resistance. This review provides an overview of the importance of antifungal resistance, the classes of antifungal agents, and their mode of action. It highlights the molecular mechanisms of antifungal drug resistance, including alterations in drug modification, activation, and availability. In addition, the review discusses the response to drugs via the regulation of multidrug efflux systems and antifungal drug-target interactions. We emphasize the importance of understanding the molecular mechanisms of antifungal drug resistance to develop effective strategies to combat the emergence of resistance and highlight the need for continued research to identify new targets for antifungal drug development and explore alternative therapeutic options to overcome resistance. Overall, an understanding of antifungal drug resistance and its mechanisms will be indispensable for the field of antifungal drug development and clinical management of fungal infections.

Indexed as

antifungal drugsantifungal resistancemultidrug effluxpathogenic fungipleiotropic drug response

Identifiers

PMID37233275
PMCPMC10219139
OpenAlexW4376254095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.