Evidence map›Paper›PMID 37233208›Full record

ArticleRadiology. Imaging cancer2023

Simultaneous Detection of Multiple Tumor-targeted Gold Nanoparticles in HER2-Positive Breast Tumors Using Optoacoustic Imaging.

Abhilash Samykutty, Karl N Thomas, Molly McNally, Jordan Hagood, Akiko Chiba, Alexandra Thomas, Libby McWilliams, Bahareh Behkam, Ying Zhan, McAlister Council-Troche and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Assessment of Breast Tumors Using Multispectral Optoacoustic Tomography in a Surgical Setting.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Abhilash SamykuttyFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.ORCID 0000-0003-3551-045X
Karl N ThomasFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.ORCID 0000-0003-1192-0737
Molly McNallyFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.ORCID 0000-0002-8172-8890
Jordan HagoodFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
Akiko ChibaFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.ORCID 0000-0003-0303-2799
Alexandra ThomasFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
Libby McWilliamsFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
Bahareh BehkamFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
Ying ZhanFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
McAlister Council-TrocheFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
Juan C Claros-SortoFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
Christina HensonFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.ORCID 0000-0002-5419-4125
Tabitha GarweFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
Zoona SarwarFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.
William E GrizzleFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.ORCID 0000-0001-9245-0401
Lacey R McNallyFrom the Department of Surgery, Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, Okla (A.S., M.M., J.H., L.M., J.C.C.S.); Department of Radiation Oncology, University of Oklahoma Health Science Center, Oklahoma City, Okla (C.H.); Atrium Wake Forest Health Comprehensive Cancer Center, Winston-Salem, NC (A.T., L.M.); Department of Surgery, Duke University, Durham, NC (A.C.); Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27013 (A.S., K.N.T., M.M., L.R.M.); Department of Mechanical Engineering, Virginia Tech University, Blacksburg, Va (B.B., Y.Z., M.C.T.); and Department of Epidemiology and Biostatistics (T.G., Z.S.) and Department of Pathology (W.E.G.), University of Alabama at Birmingham, Birmingham, Ala.ORCID 0000-0001-6756-129X
University of Oklahoma Health Sciences Center · US

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michael S. Businelle · 2018 to 2026
$27.1M
TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Timiya S Nolan · 2005 to 2026
$26.6M
Stroma Targeted Theranostic Nanoparticles for Pancreatic CancerR01CA212350 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2017 to 2021
$1.7M
Non-Invasive Detection of Tumor Extracellular pH using Multispectral Optoacoustic TomographyR01CA205941 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2021
$1.7M
NCI NIH HHS P30 CA225520NCI NIH HHS R01 CA205941NCI NIH HHS R01 CA212350NCI NIH HHS U54 CA118948
6 · The paper itself

Abstract

Purpose To develop optoacoustic, spectrally distinct, actively targeted gold nanoparticle-based near-infrared probes (trastuzumab [TRA], TRA-Aurelia-1, and TRA-Aurelia-2) that can be individually identifiable at multispectral optoacoustic tomography (MSOT) of human epidermal growth factor receptor 2 (HER2)-positive breast tumors. Materials and Methods Gold nanoparticle-based near-infrared probes (Aurelia-1 and 2) that are optoacoustically active and spectrally distinct for simultaneous MSOT imaging were synthesized and conjugated to TRA to produce TRA-Aurelia-1 and 2. Freshly resected human HER2-positive (

Indexed as

Breast NeoplasmsMammary Neoplasms, AnimalMetal NanoparticlesAnimalsFemaleGoldHumansMiceMolecular ImagingTrastuzumabGoldTrastuzumabBreast CancerMolecular ImagingNanoparticlesPhotoacoustic Imaging

Identifiers

PMID37233208
PMCPMC10240250
OpenAlexW4378348698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.