Evidence map›Paper›PMID 37233207›Full record

ArticleRadiology. Imaging cancer2023

Chemical Shift MRI Monitoring of Chemoembolization Delivery for Hepatocellular Carcinoma: Multicenter Feasibility of Initial Clinical Translation.

Andrew C Gordon, Robert J Lewandowski, Weiguo Li, Xiaodong Zhong, Stephan A R Kannengiesser, Frank H Miller, Riad Salem, William S Rilling, Andrew C Larson, Sarah B White

Open access · diamondAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Imaging cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrew C GordonFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).ORCID 0000-0002-0092-249X
Robert J LewandowskiFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).ORCID 0000-0002-5510-788X
Weiguo LiFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).ORCID 0000-0001-8125-3824
Xiaodong ZhongFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).
Stephan A R KannengiesserFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).
Frank H MillerFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).ORCID 0000-0001-9506-9411
Riad SalemFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).
William S RillingFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).
Andrew C LarsonFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).ORCID 0000-0002-1223-7406
Sarah B WhiteFrom the Department of Radiology (A.C.G., R.J.L., W.L., F.H.M., R.S., A.C.L.), Department of Medicine-Hematology/Oncology (R.J.L., R.S., A.C.L.), and Department of Surgery-Organ Transplantation (R.J.L., R.S.), Northwestern University Feinberg School of Medicine, Chicago, Ill; Siemens Medical Solutions USA, Los Angeles, Calif (X.Z.); MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany (S.A.R.K.); and Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226 (W.S.R., S.B.W.).ORCID 0000-0002-6870-6400
Siemens Healthcare (United States) · US

Funding

Cancer Nanotechnology in Imaging and RadiotherapyR25CA132822 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLOSCHAK, GAYLE E. · 2009 to 2013
$2.0M
NCI NIH HHS R25 CA132822
6 · The paper itself

Abstract

Purpose To demonstrate the feasibility of using chemical shift fat-water MRI methods to visualize and measure intrahepatic delivery of ethiodized oil to liver tumors following conventional transarterial chemoembolization (cTACE). Materials and Methods Twenty-eight participants (mean age, 66 years ± 8 [SD]; 22 men) with hepatocellular carcinoma (HCC) treated with cTACE were evaluated with follow-up chemical shift MRI in this Health Insurance Portability and Accountability Act-compliant prospective, institutional review board-approved study. Uptake of ethiodized oil was evaluated at 1-month follow-up chemical shift MRI. Measurements of tumor size (MRI and CT), attenuation and enhancement (CT), fat content percentage, and tumor:normal ratio (MRI) were compared by lesion for responders versus nonresponders, as assessed with modified Response Evaluation Criteria in Solid Tumors and European Association for the Study of the Liver (EASL) criteria. Adverse events and overall survival by the Kaplan-Meier method were secondary end points. Results Focal tumor ethiodized oil retention was 46% (12 of 26 tumors) at 24 hours and 47% (18 of 38 tumors) at 1 month after cTACE. Tumor volume at CT did not differ between EASL-defined responders and nonresponders (

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsAgedDoxorubicinEthiodized OilFeasibility StudiesHumansMagnetic Resonance ImagingMaleProspective StudiesDoxorubicinEthiodized OilChemical Shift ImagingCTEthiodized OilHepatic ChemoembolizationMRI

Identifiers

PMID37233207
PMCPMC10240251
OpenAlexW4378349009

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.