Evidence map›Paper›PMID 37232975›Full record

ArticleGels (Basel, Switzerland)2023

Chitosan-Silica Hybrid Biomaterials for Bone Tissue Engineering: A Comparative Study of Xerogels and Aerogels.

Antonio Pérez-Moreno, Manuel Piñero, Rafael Fernández-Montesinos, Gonzalo Pinaglia-Tobaruela, María V Reyes-Peces, María Del Mar Mesa-Díaz, José Ignacio Vilches-Pérez, Luis Esquivias, Nicolás de la Rosa-Fox, Mercedes Salido

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Antonio Pérez-MorenoDepartamento de Física de la Materia Condensada, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Spain.ORCID 0000-0003-1902-9455
Manuel PiñeroDepartamento de Física de la Materia Condensada, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Spain.ORCID 0000-0001-8898-4371
Rafael Fernández-MontesinosInstituto de Biomedicina de Cádiz (INIBICA), Universidad de Cadiz, 11510 Cádiz, Spain.
Gonzalo Pinaglia-TobaruelaInstituto de Biomedicina de Cádiz (INIBICA), Universidad de Cadiz, 11510 Cádiz, Spain.ORCID 0000-0002-0864-4308
María V Reyes-PecesDepartamento de Física de la Materia Condensada, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Spain.ORCID 0000-0002-7528-8331
María Del Mar Mesa-DíazInstituto de Microscopía Electrónica y Materiales (IMEYMAT), Universidad de Cadiz, 11510 Cádiz, Spain.ORCID 0000-0001-7019-3563
José Ignacio Vilches-PérezInstituto de Biomedicina de Cádiz (INIBICA), Universidad de Cadiz, 11510 Cádiz, Spain.
Luis EsquiviasDepartamento de Física de la Materia Condensada, Universidad de Sevilla, 41012 Sevilla, Spain.ORCID 0000-0002-6773-5963
Nicolás de la Rosa-FoxDepartamento de Física de la Materia Condensada, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Spain.ORCID 0000-0002-7066-5660
Mercedes SalidoInstituto de Biomedicina de Cádiz (INIBICA), Universidad de Cadiz, 11510 Cádiz, Spain.ORCID 0000-0001-9070-2257
Universidad de Cádiz · ESUniversidad de Sevilla · ES

Funding

Regional Government of Andalusia CTS 253 PAIDIRegional Government of Andalusia FEDER/ITI 2014-2020Regional Government of Andalusia TEP115 PAIDI
6 · The paper itself

Abstract

Chitosan (CS) is a natural biopolymer that shows promise as a biomaterial for bone-tissue regeneration. However, because of their limited ability to induce cell differentiation and high degradation rate, among other drawbacks associated with its use, the creation of CS-based biomaterials remains a problem in bone tissue engineering research. Here we aimed to reduce these disadvantages while retaining the benefits of potential CS biomaterial by combining it with silica to provide sufficient additional structural support for bone regeneration. In this work, CS-silica xerogel and aerogel hybrids with 8 wt.% CS content, designated SCS8X and SCS8A, respectively, were prepared by sol-gel method, either by direct solvent evaporation at the atmospheric pressure or by supercritical drying in CO

Indexed as

aerogelbioactivitybone healingchitosanfocal adhesionmechanotransductionosteoconductionxerogel

Identifiers

PMID37232975
PMCPMC10217634
OpenAlexW4375862405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.