Evidence map›Paper›PMID 37232918›Full record

ReviewBiosensors2023

Molecular Fingerprint Detection Using Raman and Infrared Spectroscopy Technologies for Cancer Detection: A Progress Review.

Shuyan Zhang, Yi Qi, Sonia Peng Hwee Tan, Renzhe Bi, Malini Olivo

Abstract readReview
In one paragraph

Review in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  19. Metasurface-enhanced biomedical spectroscopy.Nanophotonics (Berlin, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuyan ZhangInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #07-01, Singapore 138634, Singapore.ORCID 0000-0002-1286-4856
Yi QiInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #07-01, Singapore 138634, Singapore.
Sonia Peng Hwee TanDepartment of Biomedical Engineering, National University of Singapore (NUS), 4 Engineering Drive 3 Block 4, #04-08, Singapore 117583, Singapore.
Renzhe BiInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #07-01, Singapore 138634, Singapore.ORCID 0000-0001-7173-064X
Malini OlivoInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #07-01, Singapore 138634, Singapore.

Funding

Agency for Science, Technology and Research BMRC Central Research Fund (ATR) 2021 and Horizontal Technology Programme Office Seed Fund, Biomedical Engineering Programme 2021, C211318004Agency for Science, Technology and Research Career Development Award (202D800042)
6 · The paper itself

Abstract

Molecular vibrations play a crucial role in physical chemistry and biochemistry, and Raman and infrared spectroscopy are the two most used techniques for vibrational spectroscopy. These techniques provide unique fingerprints of the molecules in a sample, which can be used to identify the chemical bonds, functional groups, and structures of the molecules. In this review article, recent research and development activities for molecular fingerprint detection using Raman and infrared spectroscopy are discussed, with a focus on identifying specific biomolecules and studying the chemical composition of biological samples for cancer diagnosis applications. The working principle and instrumentation of each technique are also discussed for a better understanding of the analytical versatility of vibrational spectroscopy. Raman spectroscopy is an invaluable tool for studying molecules and their interactions, and its use is likely to continue to grow in the future. Research has demonstrated that Raman spectroscopy is capable of accurately diagnosing various types of cancer, making it a valuable alternative to traditional diagnostic methods such as endoscopy. Infrared spectroscopy can provide complementary information to Raman spectroscopy and detect a wide range of biomolecules at low concentrations, even in complex biological samples. The article concludes with a comparison of the techniques and insights into future directions.

Indexed as

NeoplasmsSpectrum Analysis, RamanChemistry, PhysicalHumansSpectrophotometry, Infraredbiomarkerbiomedicalbiosensorcancer diagnosisinfrared spectroscopymolecular fingerprintRaman spectroscopyvibrational spectroscopy

Identifiers

PMID37232918
PMCPMC10216688

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.