Evidence map›Paper›PMID 37232798›Full record

SynthesisCurrent oncology (Toronto, Ont.)2023

The Role of Preoperative Chemotherapy in the Management of Synchronous Resectable Colorectal Liver Metastases: A Meta-Analysis.

Kostas Tepelenis, Georgios Pappas-Gogos, Panagiotis Ntellas, Konstantinos Tsimogiannis, Katerina Dadouli, Davide Mauri, Georgios K Glantzounis

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current oncology (Toronto, Ont.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kostas TepelenisHepatobiliary and Pancreatic Surgery (HPB) Unit, Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.
Georgios Pappas-GogosHepatobiliary and Pancreatic Surgery (HPB) Unit, Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.
Panagiotis NtellasDepartment of Oncology, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.
Konstantinos TsimogiannisHepatobiliary and Pancreatic Surgery (HPB) Unit, Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.ORCID 0000-0002-4390-3029
Katerina DadouliLaboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, 382 21 Larisa, Greece.ORCID 0000-0002-8821-0795
Davide MauriDepartment of Oncology, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.
Georgios K GlantzounisHepatobiliary and Pancreatic Surgery (HPB) Unit, Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece.
University of Ioannina · GRDemocritus University of Thrace · GRUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe indications of preoperative chemotherapy, for initially resectable synchronous colorectal liver metastases, remain controversial. This meta-analysis aimed to assess the efficacy and safety of preoperative chemotherapy in such patients.

methodsSix retrospective studies were included in the meta-analysis with 1036 patients. Some 554 patients were allocated to the preoperative group, and 482 others were allocated to the surgery group.

resultsMajor hepatectomy was more common in the preoperative group than in the surgery group (43.1% vs. 28.8%,

conclusionsPreoperative chemotherapy should be suggested in patients with high disease burden. The number of cycles of preoperative chemotherapy should be low (3-4) to avoid increased postoperative morbidity. However more prospective studies are needed to clarify the exact role of preoperative chemotherapy in patients with synchronous resectable colorectal liver metastases.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsChemotherapy, AdjuvantHumansNeoplasm Recurrence, LocalRetrospective Studiesneoadjuvant chemotherapypreoperative chemotherapyresectable colorectal liver metastasesstage IV colorectal cancersynchronous colorectal liver metastases

Identifiers

PMID37232798
PMCPMC10217056
OpenAlexW4367189194

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.