Evidence map›Paper›PMID 37232738›Full record

ArticleCurrent issues in molecular biology2023

The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential.

Mohammed Ghiboub, Matthew Bell, Dovile Sinkeviciute, Rab K Prinjha, Menno P J de Winther, Nicola R Harker, David F Tough, Wouter J de Jonge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Mohammed GhiboubTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 BK Amsterdam, The Netherlands.ORCID 0000-0002-2095-371X
Matthew BellImmunology Research Unit, Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, UK.ORCID 0000-0002-7314-7383
Dovile SinkeviciuteImmunology Research Unit, Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, UK.ORCID 0000-0003-4275-388X
Rab K PrinjhaImmunology Research Unit, Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, UK.
Menno P J de WintherDepartment of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-4038-6636
Nicola R HarkerImmunology Research Unit, Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, UK.
David F ToughImmunology Research Unit, Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, UK.ORCID 0000-0003-3585-0649
Wouter J de JongeTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology Metabolism, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, 1105 BK Amsterdam, The Netherlands.ORCID 0000-0002-3241-1547
GlaxoSmithKline (United Kingdom) · GBInstitute for Sports Medicine · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between

Indexed as

dendritic cellsGSK761maturationSP140tolerogenic potential

Identifiers

PMID37232738
PMCPMC10217447
OpenAlexW4376137603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.