Evidence map›Paper›PMID 37232485›Full record

ReviewExperimental physiology2023

Myths and methodologies: Cardiopulmonary exercise testing for surgical risk stratification in patients with an abdominal aortic aneurysm; balancing risk over benefit.

Damian M Bailey, Richard G Davies, George A Rose, Michael H Lewis, Ahmed Abd Aldayem, Chistopher P Twine, Wael Awad, Matti Jubouri, Idhrees Mohammed, Carlos A Mestres and 5 more

Abstract readReview
In one paragraph

Review in Experimental physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Damian M BaileyNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.ORCID 0000-0003-0498-7095
Richard G DaviesNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.
George A RoseNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.ORCID 0000-0002-9598-6372
Michael H LewisNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.
Ahmed Abd AldayemDepartment of Vascular Surgery, University Hospital of Wales, Cardiff, UK.
Chistopher P TwineDepartment of Surgery, University of Bristol, Bristol, UK.
Wael AwadNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.
Matti JubouriHull York Medical School, University of York, York, UK.
Idhrees MohammedInstitute of Cardiac and Aortic Disorders, SRM Institutes for Medical Science (SIMS Hospital), Chennai, Tamil Nadu, India.
Carlos A MestresDepartment of Cardiac Surgery, University Hospital Zürich, Zürich, Switzerland.
Edward P ChenDivision of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Joseph S CoselliDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Ian M WilliamsNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.
Mohamad BashirNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.
International Academic Surgical Consortium (THALAMUS)Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extent to which patients with an abdominal aortic aneurysm (AAA) should exercise remains unclear, given theoretical concerns over the perceived risk of blood pressure-induced rupture, which is often catastrophic. This is especially pertinent during cardiopulmonary exercise testing, when patients are required to perform incremental exercise to symptom-limited exhaustion for the determination of cardiorespiratory fitness. This multimodal metric is being used increasingly as a complementary diagnostic tool to inform risk stratification and subsequent management of patients undergoing AAA surgery. In this review, we bring together a multidisciplinary group of physiologists, exercise scientists, anaesthetists, radiologists and surgeons to challenge the enduring 'myth' that AAA patients should be fearful of and avoid rigorous exercise. On the contrary, by appraising fundamental vascular mechanobiological forces associated with exercise, in conjunction with 'methodological' recommendations for risk mitigation specific to this patient population, we highlight that the benefits conferred by cardiopulmonary exercise testing and exercise training across the continuum of intensity far outweigh the short-term risks posed by potential AAA rupture.

Indexed as

Aortic Aneurysm, AbdominalCardiorespiratory FitnessExercise TestHumansRisk AssessmentRisk Factorsabdominal aortic aneurysmcardiopulmonary exercise testingperioperative outcomerupturesurgical risk stratification

Identifiers

PMID37232485
PMCPMC10988440

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.