ArticleJournal of the American Heart Association2023
Reducing Long-Term Mortality Post Transcatheter Aortic Valve Replacement Requires Systemic Differentiation of Patient-Specific Coronary Hemodynamics.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Geometric Determinants of Post-stenotic Energetics in Coarctation of Aorta: Linking Centerline Morphology to Downstream Energy Loss.Annals of biomedical engineering · 2026Article
- TAVR in Male Patients With Large Aortic Valve Annuli: A Propensity-Matched Analysis of Balloon-Expandable Versus Self-Expanding Valves.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Triglyceride-glucose index predicts early, short-term, and long-term mortality after transcatheter aortic valve replacement.American heart journal plus : cardiology research and practice · 2026Article
- Machine learning methods to predict transvalvular gradient waveform post-transcatheter aortic valve replacement using preprocedural echocardiogram.The Journal of thoracic and cardiovascular surgery · 2025Article
- The Virtual Transcatheter Aortic Valve Replacement (VTAVR) framework predicts optimal device landing zones tailored to patient-specific anatomy.npj biomedical innovations · 2025Article
- Article
- Regional assessment of aortic valve calcification using topographic maps in contrast-enhanced CT:Quantitative imaging in medicine and surgery · 2024Article
- Incremental prognostic value of intensity-weighted regional calcification scoring using contrast CT imaging in TAVR.European heart journal. Imaging methods and practice · 2023Article
- Impact of TAVR on coronary artery hemodynamics using clinical measurements and image-based patient-specific in silico modeling.Scientific reports · 2023Article
- A Doppler-exclusive non-invasive computational diagnostic framework for personalized transcatheter aortic valve replacement.Scientific reports · 2023Article
- Ventricular pressure-volume loop and other heart-function metrics can elucidate etiology of failure of TAVI and interventions.REC, interventional cardiologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Despite the proven benefits of transcatheter aortic valve replacement (TAVR) and its recent expansion toward the whole risk spectrum, coronary artery disease is present in more than half of the candidates for TAVR. Many previous studies do not focus on the longer-term impact of TAVR on coronary arteries, and hemodynamic changes to the circulatory system in response to the anatomical changes caused by TAVR are not fully understood. Methods and Results We developed a multiscale patient-specific computational framework to examine the effect of TAVR on coronary and cardiac hemodynamics noninvasively. Based on our findings, TAVR might have an adverse impact on coronary hemodynamics due to the lack of sufficient coronary blood flow during diastole phase (eg, maximum coronary flow rate reduced by 8.98%, 16.83%, and 22.73% in the left anterior descending, left circumflex coronary artery, and right coronary artery, respectively [N=31]). Moreover, TAVR may increase the left ventricle workload (eg, left ventricle workload increased by 2.52% [N=31]) and decrease the coronary wall shear stress (eg, maximum time averaged wall shear stress reduced by 9.47%, 7.75%, 6.94%, 8.07%, and 6.28% for bifurcation, left main coronary artery, left anterior descending, left circumflex coronary artery, and right coronary artery branches, respectively). Conclusions The transvalvular pressure gradient relief after TAVR might not result in coronary flow improvement and reduced cardiac load. Optimal revascularization strategy pre-TAVR and progression of coronary artery disease after TAVR could be determined by noninvasive personalized computational modeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.