Evidence map›Paper›PMID 37232020›Full record

ArticleBritish journal of pharmacology2023

Complementary roles of EP2 and EP4 receptors in malignant glioma.

Jiange Qiu, Qianqian Li, Junqi Li, Fengmei Zhou, Peng Sang, Zhongkun Xia, Wei Wang, Lin Wang, Ying Yu, Jianxiong Jiang

Open access · greenAbstract read
In one paragraph

Article in British journal of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Targeting the COX-2/PGECancer immunology, immunotherapy : CII · 2026
    Review
  3. Neuroinflammation and Disease: Pathways and Opportunities.Annual review of pharmacology and toxicology · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Regulatory Effect of PGEBiomolecules · 2025
    Article
  8. Review
  9. Strategies for Overcoming Immune Evasion in Bladder Cancer.International journal of molecular sciences · 2024
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jiange QiuAcademy of Medical Science, Zhengzhou University, Zhengzhou, China.
Qianqian LiDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0001-7721-9834
Junqi LiMedical Research Center, Institute of Neuroscience, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Fengmei ZhouAcademy of Medical Science, Zhengzhou University, Zhengzhou, China.
Peng SangAcademy of Medical Science, Zhengzhou University, Zhengzhou, China.
Zhongkun XiaAcademy of Medical Science, Zhengzhou University, Zhengzhou, China.
Wei WangAcademy of Medical Science, Zhengzhou University, Zhengzhou, China.
Lin WangAcademy of Medical Science, Zhengzhou University, Zhengzhou, China.
Ying YuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jianxiong JiangDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0003-3955-8928
Zhengzhou University · CNUniversity of Tennessee Health Science Center · USThird Affiliated Hospital of Zhengzhou University · CN

Funding

Inflammatory regulation of neurotrophin signaling in epileptogenesisR01NS100947 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Jianxiong Jiang · 2018 to 2026
$2.8M
NINDS NIH HHS R01 NS100947
6 · The paper itself

Abstract

background and purposeGlioblastoma (GBM) is the most aggressive brain tumour in the central nervous system, but the current treatment is very limited and unsatisfactory. PGE EXPERIMENTAL APPROACH: We performed comprehensive data analysis of gene expression in human GBM samples and determined their expression correlations through multiple bioinformatics approaches. A time-resolved fluorescence energy transfer (TR-FRET) assay was utilized to characterize PGE KEY

resultsThe expression of both EP CONCLUSION AND IMPLICATIONS: The compensatory roles of EP

Indexed as

GlioblastomaGliomaDinoprostoneHumansReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeDinoprostonePTGER2 protein, humanPTGER4 protein, humanReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeantagonistCOXGBMglioblastomaPD-L1prostaglandintumour inflammationtumour microenvironment

Identifiers

PMID37232020
PMCPMC10524591
OpenAlexW4378348411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.