Evidence map›Paper›PMID 37231893›Full record

ArticleFetal diagnosis and therapy2023

Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System.

Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than and 1 more

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In one paragraph

Article in Fetal diagnosis and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Priya PrasadPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Roberto RomeroPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Tinnakorn ChaiworapongsaPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Nardhy Gomez-LopezPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Anderson LoPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Jose GalazPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Andreea B TaranPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Eunjung JungPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Francesca GotschPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Nandor Gabor ThanPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Adi L TarcaPregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Department of Health and Human Services National Institute of Child Health and Human Development, National Institutes of Health, U. S., Bethesda, MD, and, Detroit, Michigan, USA.
Wayne State University · USNational Institute of Child Health · HUSemmelweis University · HUUniversity of Michigan · US

Funding

Prenatal Diagnosis Of Congenital AnomaliesZIAHD002401 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROMERO, ROBERTO · 2009 to 2025
$81.1M
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITIONZ01HD002400 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROMERO, ROBERTO · 1992 to 2008
$8.2M
Intramural NIH HHS Z01 HD002400NICHD NIH HHS HHSN275201300006C
6 · The paper itself

Abstract

introductionApproximately 47% of women with an episode of preterm labor deliver at term; however, their infants are at greater risk of being small for gestational age and for neurodevelopmental disorders. In these cases, a pathologic insult may disrupt the homeostatic responses sustaining pregnancy. We tested the hypothesis of an involvement of components of the insulin-like growth factor (IGF) system.

methodsThis is a cross-sectional study in which maternal plasma concentrations of pregnancy-associated plasma protease (PAPP)-A, PAPP-A2, insulin-like growth factor-binding protein 1 (IGFBP-1), and IGFBP-4 were determined in the following groups of women: (1) no episodes of preterm labor, term delivery (controls, n = 100); (2) episode of preterm labor, term delivery (n = 50); (3) episode of preterm labor, preterm delivery (n = 100); (4) pregnant women at term not in labor (n = 61); and (5) pregnant women at term in labor (n = 61). Pairwise differences in maternal plasma concentrations of PAPP-A, PAPP-A2, IGFBP-1, and IGFBP-4 among study groups were assessed by fitting linear models on log-transformed data and included adjustment for relevant covariates. Significance of the group coefficient in the linear models was assessed via t-scores, with p < 0.05 deemed a significant result.

resultsCompared to controls, (1) women with an episode of premature labor, regardless of a preterm or a term delivery, had higher mean plasma concentrations of PAPP-A2 and IGFBP-1 (each p < 0.05); (2) women with an episode of premature labor who delivered at term also had a higher mean concentration of PAPP-A (p < 0.05); and (3) acute histologic chorioamnionitis and spontaneous labor at term were not associated with significant changes in these analytes.

conclusionAn episode of preterm labor involves the IGF system, supporting the view that the premature activation of parturition is a pathologic state, even in those women who delivered at term.

Indexed as

ChorioamnionitisObstetric Labor, PrematureSomatomedinsAmniotic FluidCross-Sectional StudiesFemaleHumansInfant, NewbornInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 4PregnancyPregnancy-Associated Plasma Protein-AInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 4Pregnancy-Associated Plasma Protein-ASomatomedinsBiomarkerHistologic chorioamnionitisIGFBP-1IGFBP-4Intra-amniotic infection/inflammationPAPP-APAPP-A2Placental pathologyPreterm birth

Identifiers

PMID37231893
PMCPMC10591834
OpenAlexW4378348811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.