Evidence map›Paper›PMID 37231878›Full record

ArticleObesity facts2023

Soluble (Pro)Renin Receptor Level in Patients with Severe Obesity Is Associated with Visceral Adiposity and Is Involved with Insulin Resistance and Renal Injury.

Takashi Yamaguchi, Satoshi Morimoto, Chikahito Suda, Atsuhiro Ichihara, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Masahiro Ohira and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity facts, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Takashi YamaguchiCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Satoshi MorimotoDepartment of Endocrinology and Hypertension, Tokyo Womens' Medical University, Tokyo, Japan.
Chikahito SudaDepartment of Endocrinology and Hypertension, Tokyo Womens' Medical University, Tokyo, Japan.
Atsuhiro IchiharaDepartment of Endocrinology and Hypertension, Tokyo Womens' Medical University, Tokyo, Japan.
Noriko IshiharaClinical Laboratory Program, Faculty of Science, Toho University, Chiba, Japan.
Shoko NakamuraCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Sho TanakaCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Yasuhiro WatanabeCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Haruki ImamuraCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Masahiro OhiraDivision of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University Medical Center, Tokyo, Japan.
Naomi ShimizuCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Atsuhito SaikiCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Ichiro TatsunoCenter of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Toho University · JPTokyo Women's Medical University · JPChiba Prefectural University of Health Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHigh soluble (pro)renin receptor (s[P]RR) level in circulation is reported in obese patients; however, it is unclear which body composition components are responsible for it. In this study, the authors examined blood s(P)RR levels and ATP6AP2 gene expression levels in visceral and subcutaneous adipose tissue (VAT, SAT) in severely obese patients who underwent laparoscopic sleeve gastrectomy (LSG), with the aim of clarifying the relationship with body composition and metabolic factors.

methodsSeventy five cases who underwent LSG between 2011 and 2015 and were postoperatively followed-up for 12 months at the Toho University Sakura Medical Center were included in the analysis of the cross-sectional survey at baseline, and 33 cases were included in the analysis of the longitudinal survey during the 12 months after LSG. We evaluated body composition, glycolipid parameters, liver/renal function, as well as serum s(P)RR level and ATP6AP2 mRNA expression level in VAT and SAT.

resultsThe mean serum s(P)RR level at baseline was 26.1 ng/mL, this value was considered higher than values in healthy subjects. There was no significant difference in the expression level of ATP6AP2 mRNA between VAT and SAT. At baseline, multiple regression analysis for the association between s(P)RR and variables identified that visceral fat area, HOMA2-IR, and UACR showed the independent relationships with s(P)RR. During the 12 months after LSG, body weight, serum s(P)RR level showed a significant decrease (from 30.0 ± 7.0 to 21.9 ± 4.3). Multiple regression analysis for the association between the change in s(P)RR and variables showed that changes in visceral fat area, and alanine transaminase were independently related to the change in s(P)RR.

conclusionThis study showed that blood s(P)RR level was high in severely obese patients, decreased with weight loss by LSG, and was associated with visceral fat area in both pre- and postoperative changes. The results suggest that blood s(P)RR levels in obese patients may reflect the involvement of visceral adipose (P)RR in insulin resistance and renal damage mechanisms associated with obesity.

Indexed as

Insulin ResistanceObesity, MorbidAdiposityCross-Sectional StudiesHumansIntra-Abdominal FatKidneyObesityProrenin ReceptorATP6AP2 protein, humanProrenin ReceptorObesityProreninSoluble (pro)renin receptorVisceral adiposity

Identifiers

PMID37231878
PMCPMC10427953
OpenAlexW4378349060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.