Evidence map›Paper›PMID 37231780›Full record

ArticleBioconjugate chemistry2023

Cellular Uptake Mechanism of Nucleic Acid Nanocapsules and Their DNA-Surfactant Building Blocks.

Suman Pal, Ina F de la Fuente, Shraddha S Sawant, Jenna N Cannata, Wu He, Jessica L Rouge

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Suman PalDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0003-3852-4857
Ina F de la FuenteDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
Shraddha S SawantDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0001-6858-7635
Jenna N CannataDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
Wu HeFlow Cytometry Facility, Center for Open Research Resources and Equipment, University of Connecticut, Storrs, Connecticut 06269, United States.
Jessica L RougeDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0002-6051-3735
University of Connecticut · US

Funding

Achieving enhanced cytosolic delivery and greater efficacy of therapeutic nucleic acids using DNA-surfactant conjugatesR35GM138226 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI Jessica L Rouge · 2020 to 2026
$2.4M
Leica TCS SP8 FSU AOBS 405 UV Spectral Confocal MicroscopeS10OD016435 · OD · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2014 to 2014
$456k
NIGMS NIH HHS R35 GM138226NIH HHS S10 OD016435
6 · The paper itself

Abstract

Nucleic acid nanocapsules (NANs) are enzyme-responsive DNA-functionalized micelles built for the controlled release of DNA-surfactant conjugates (DSCs) that present sequences with demonstrated therapeutic potential. Here, we investigate the mechanisms by which DSCs gain access to intracellular space

Indexed as

NanocapsulesNucleic AcidsBiological TransportDNAEndocytosisSurface-Active AgentsDNANanocapsulesNucleic AcidsSurface-Active Agents

Identifiers

PMID37231780
PMCPMC10330902
OpenAlexW4378348385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.