Evidence map›Paper›PMID 37231685›Full record

ArticleEuropean stroke journal2023

Etiology and risk factors of ischemic stroke during pregnancy and puerperium: A population-based study.

Anna Richardt, Karoliina Aarnio, Aino Korhonen, Kirsi Rantanen, Liisa Verho, Hannele Laivuori, Mika Gissler, Minna Tikkanen, Petra Ijäs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Anna RichardtDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-1739-3344
Karoliina AarnioDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Aino KorhonenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Kirsi RantanenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Liisa VerhoDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hannele LaivuoriDepartment of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mika GisslerDepartment of Knowledge Brokers, Finnish Institute for Health and Welfare, Helsinki, Finland.
Minna TikkanenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Petra IjäsDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-7292-1971
University of Helsinki · FIKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIschemic stroke (IS) is an uncommon, but potentially life-changing, complication of pregnancy. The aim of this study was to analyze the etiology and risk factors of pregnancy-associated IS. PATIENTS AND

methodsWe collected a population-based retrospective cohort of patients diagnosed with IS during pregnancy or puerperium in Finland from 1987 to 2016. These women were identified by linking the Medical Birth Register (MBR) with the Hospital Discharge Register. Three matched controls were selected from MBR for each case. The diagnosis and temporal relationship of IS to pregnancy, and clinical details were verified from patient records.

resultsA total of 97 women (median age 30.7 years) were identified as having pregnancy-associated IS. The most common etiologies based on TOAST classification were cardioembolism in 13 (13.4%), other determined in 27 (27.8%) and undetermined in 55 (56.7%) patients. Fifteen patients (15.5%) had embolic strokes of undetermined sources. The most important risk factors were pre-eclampsia, eclampsia, gestational hypertension, and migraine. IS patients had more frequently traditional and pregnancy-related stroke risk factors than the controls (OR 2.38, 95% CI 1.48-3.84) and the risk of IS multiplied with the number of risk factors (4-5 risk factors: OR 14.21, 95% CI 1.12-180.48). DISCUSSION AND

conclusionRare causes and cardioembolism were frequent etiologies for pregnancy-associated IS, but in half of the women, the etiology remained undetermined. The risk of IS increased with the number of risk factors. Surveillance and counseling of pregnant women, especially with multiple risk factors, is crucial for the prevention of pregnancy-associated IS.

Indexed as

Ischemic StrokeStrokeAdultFemaleHumansPostpartum PeriodPregnancyRetrospective StudiesRisk FactorsetiologyIschemic strokepostpartum periodpregnancypuerperiumrisk factorsstroke

Identifiers

PMID37231685
PMCPMC10334185
OpenAlexW4366989160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.