Evidence map›Paper›PMID 37231429›Full record

ArticleTrials2023

Evaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial.

Wataru Kagaya, Chim W Chan, James Kongere, Bernard N Kanoi, Mtakai Ngara, Protus Omondi, Ashley Osborne, Laura Barbieri, Achyut Kc, Noboru Minakawa and 2 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Wataru KagayaDepartment of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. wataru.kagaya@gmail.com.ORCID http://orcid.org/0000-0003-0998-5267
Chim W ChanDepartment of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
James KongereDepartment of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Bernard N KanoiDirectorate of Research and Innovation, Mount Kenya University, Thika, Kenya.
Mtakai NgaraDirectorate of Research and Innovation, Mount Kenya University, Thika, Kenya.
Protus OmondiDepartment of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Ashley OsborneFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Laura BarbieriDepartment of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Achyut KcDepartment of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Noboru MinakawaDepartment of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Jesse GitakaDirectorate of Research and Innovation, Mount Kenya University, Thika, Kenya.
Akira KanekoDepartment of Virology and Parasitology/Research Center for Infectious Diseases, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Osaka Metropolitan University · JPMount Kenya University · KEKarolinska Institutet · SELondon School of Hygiene & Tropical Medicine · GBNagasaki University · JP

Funding

Japan Agency for Medical Research and Development 20JM0110020H0002
6 · The paper itself

Abstract

backgroundIn the Lake Victoria Basin of western Kenya, malaria remains highly endemic despite high coverage of interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective effect of LLINs is hampered by insecticide resistance in Anopheles vectors and its repurposing by the community. Ceiling nets and LLIN with synergist piperonyl butoxide (PBO-LLIN) are novel tools that can overcome the problems of behavioral variation of net use and metabolic resistance to insecticide, respectively. The two have been shown to reduce malaria prevalence when used independently. Integration of these two tools (i.e., ceiling nets made with PBO-LLIN or Olyset®Plus ceiling nets) appears promising in further reducing the malaria burden.

methodsA cluster-randomized controlled trial is designed to assess the effect of Olyset®Plus ceiling nets on reducing malaria prevalence in children on Mfangano Island in Homa Bay County, where malaria transmission is moderate. Olyset®Plus ceiling nets will be installed in 1315 residential structures. Malaria parasitological, entomological, and serological indicators will be measured for 12 months to compare the effectiveness of this new intervention against conventional LLIN in the control arm. DISCUSSION: Wider adoption of Olyset®Plus ceiling nets to complement existing interventions may benefit other malaria-endemic counties and be incorporated as part of Kenya's national malaria elimination strategy.

trial registrationUMIN Clinical Trials Registry UMIN000045079. Registered on 4 August 2021.

Indexed as

InsecticidesInsecticide-Treated BednetsMalariaAnimalsChildHumansInsecticide ResistanceKenyaLakesMosquito ControlMosquito VectorsPrevalenceRandomized Controlled Trials as TopicInsecticidesAnopheles mosquitoCeiling netCluster-randomized controlled trialKenyaLLINMalariaPyrethroid resistanceVector control

Identifiers

PMID37231429
PMCPMC10210418
OpenAlexW4378226956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.