SynthesisBMC musculoskeletal disorders2023
How effective is diluted povidone-iodine in preventing periprosthetic joint infection in total joint arthroplasty (TJA)? An updated systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Evaluating the impact of povidone-iodine irrigation on microbial contamination in reverse total shoulder arthroplasty.Bone & joint research · 2026Article
- Risk-stratified association between dilute povidone-iodine lavage and SSI/PJI after primary total hip arthroplasty.SICOT-J · 2026Article
- Surgical approaches in total hip arthroplasty do not influence the bacterial spectrum of acute postoperative periprosthetic joint infections.Journal of bone and joint infection · 2025Article
- Preventive strategies to reduce the rate of periprosthetic infections in total joint arthroplasty; a comprehensive review.Archives of orthopaedic and trauma surgery · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePeriprosthetic joint infection (PJI) is a serious complication with total joint arthroplasty (TJA), that necessitates reoperation. Pre-closure irrigation with dilute povidone-iodine (PI) is among the preventive measures, but its efficiency is still controversial. As a result, the focus of this systematic review and meta-analysis is on the effect of dilute PI wound irrigation in the prevention of PJI following TJA.
methodsWe systematically reviewed and analyzed articles that compared PI with other agents in terms of PJI rate after TJA, searching Medline, Scopus, Web of science, and Cochrane databases. A number of 13 papers including 63,950 patients in total, were finally considered in qualitative and quantitative assessments. We have also further assessed review articles.
resultsIn comparison with normal saline (NS), PI reduced post-operative infection rate (OR: 0.44; CI 95%: 0.34-0.56). However, there was no difference between PI and chlorhexidine (CHG) (OR: 1.61; CI 95%: 0.83-3.09)) or undetermined comparators (OR: 1.08; CI 95%: 0.67-1.76).
conclusionPI irrigation seems an efficient preventive measure for post-operative PJI and would seem to be the most feasible for TJA protocol.
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