Evidence map›Paper›PMID 37231349›Full record

ArticleBMC gastroenterology2023

Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals.

Kazuto Tajiri, Kazuhiko Okada, Hiroyuki Ito, Kengo Kawai, Yoshiro Kashii, Yoshiharu Tokimitsu, Nozomu Muraishi, Aiko Murayama, Yuka Hayashi, Masami Minemura and 3 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Refractory ITP: revisiting definitions, diagnostics, and management paradigms.Hematology. American Society of Hematology. Education Program · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kazuto TajiriThird Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, 2630 Sugitani, 930-0194, Japan. tajikazu@med.u-toyama.ac.jp.
Kazuhiko OkadaGastroenterology, Toyama Red Cross Hospital, Toyama, 930-8562, Japan.
Hiroyuki ItoGastroenterology, Takaoka Municipal Hospital, Takaoka, 933-8550, Japan.
Kengo KawaiGastroenterology, Nanto Municipal Hospital, Nanto, 932-0211, Japan.
Yoshiro KashiiGastroenterology, Saiseikai Toyama Hospital, Toyama, 931-8533, Japan.
Yoshiharu TokimitsuGastroenterology, Toyama Red Cross Hospital, Toyama, 930-8562, Japan.
Nozomu MuraishiThird Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, 2630 Sugitani, 930-0194, Japan.
Aiko MurayamaThird Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, 2630 Sugitani, 930-0194, Japan.
Yuka HayashiThird Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, 2630 Sugitani, 930-0194, Japan.
Masami MinemuraThird Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, 2630 Sugitani, 930-0194, Japan.
Terumi TakaharaThird Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, 2630 Sugitani, 930-0194, Japan.
Yukihiro ShimizuGastroenterology, Nanto Municipal Hospital, Nanto, 932-0211, Japan.
Ichiro YasudaThird Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, 2630 Sugitani, 930-0194, Japan.
University of Toyama · JPKouseiren Takaoka Hospital · JPToyama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombocytopenia due to hypersplenism is a major complication of hepatitis C virus (HCV)-associated cirrhosis. HCV eradication improves these complications in some patients, but the long-term effects of HCV eradication on these complications remain unclear, especially in patients treated with direct acting antivirals (DAAs). The aim was to evaluate long term changes in thrombocytopenia and leucopenia after HCV eradication with DAAs.

methodsThe present multicenter study retrospectively evaluated changes over 5 years in thrombocytopenia and leukocytopenia, as well as changes in liver fibrosis markers and spleen size, in 115 patients with HCV-cirrhosis treated with DAAs.

resultsThrombocytopenia and leukocytopenia were improved 4 weeks after DAA administration, with thrombocytopenia show further gradual improvement over the next year. Fib-4 index was markedly reduced 1 year after DAA, followed by subsequent gradual reduction over the next 4 years. Spleen size showed gradual annual reductions, with patients experiencing spleen size reduction characterized at baseline by bilirubinemia.

conclusionsRapid DAA-associated HCV eradication might lead to rapid disappearance of liver inflammation and bone marrow suppression due to HCV infection. HCV eradication may gradually improve portal hypertension, reducing spleen size.

Indexed as

Hepatitis CHepatitis C, ChronicLeukopeniaThrombocytopeniaAntiviral AgentsHepacivirusHumansLiver CirrhosisRetrospective StudiesAntiviral AgentsDirect-acting antiviralHepatitis C virusHypersplenismThrombocytopenia

Identifiers

PMID37231349
PMCPMC10210476
OpenAlexW4378230498

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.