ReviewNeurocritical care2023
Therapies for Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage.
Review in Neurocritical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07149922 (Early Blood Pressure Intervention After Coiling or Clipping for Subarachnoid Hemorrhage), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Blood Pressure Intervention After Coiling or Clipping for Subarachnoid Hemorrhage
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Combination of Albumin and Cilostazol Improves Outcomes in a Rodent Model of Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2026Article
- Pharmaceutically Assisted Angioplasty to Relieve Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage-A Retrospective, Single-Center, Observational Comparison of Established and New Treatment Techniques.Cardiovascular and interventional radiology · 2026Observational
- Development and internal validation of a macrophage migration inhibitory factor-based risk assessment model for delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage.Frontiers in surgery · 2026Article
- Individualized treatment for pediatric intracranial aneurysms in China: case series and literature review.Frontiers in surgery · 2026Article
- Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2025Observational
- Neuroprotective effects of hesperidin on cerebral vasospasm after subarachnoid hemorrhage in rats: an experimental study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- The TREM1-AQP4 axis mediates neuroinflammatory injury and brain edema after experimental subarachnoid hemorrhage.European journal of medical research · 2025Article
- Early Microcirculatory Dysfunction on Perfusion CT Is Related to Prognosis After Aneurysmal Subarachnoid Hemorrhage.Translational stroke research · 2025Article
- Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a narrative review.Arquivos de neuro-psiquiatria · 2025Review
- Article
- Factors Influencing the Mortality of Patients with Subarachnoid Haemorrhage in the Intensive Care Unit: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Outcomes Measures in Subarachnoid Hemorrhage Research.Translational stroke research · 2025Review
- High-Grade Subarachnoid Hemorrhage - Beyond Guidelines.Neurologic clinics · 2025Review
- Repetitive intraarterial therapy with Milrinone and Nimodipine for severe refractory Vasospasm: own series and narrative literature review.Brain & spine · 2025Article
- Individualized autoregulation-guided arterial blood pressure management in neurocritical care.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Relationship between cumulative blood pressure exposure within the early brain injury time window and delayed cerebral ischemia and rebleeding in patients with aneurysmal subarachnoid hemorrhage after aneurysm clipping: a retrospective study.Neurosurgical review · 2024Article
- Sex Differences in Outcome of Aneurysmal Subarachnoid Hemorrhage and Its Relation to Postoperative Cerebral Ischemia.Neurocritical care · 2024Article
- The Authors Reply: Sex Differences in Outcome of Aneurysmal Subarachnoid Hemorrhage and its Relation to Postoperative Cerebral Ischemia.Neurocritical care · 2024Article
- The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining.Current issues in molecular biology · 2024Article
- Premature newborns with intraventricular hemorrhage do not have vasospasm pattern by cranial Doppler ultrasound: A pilot study.European journal of pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delayed cerebral ischemia (DCI) is one of the most important complications of subarachnoid hemorrhage. Despite lack of prospective evidence, medical rescue interventions for DCI include hemodynamic augmentation using vasopressors or inotropes, with limited guidance on specific blood pressure and hemodynamic parameters. For DCI refractory to medical interventions, endovascular rescue therapies (ERTs), including intraarterial (IA) vasodilators and percutaneous transluminal balloon angioplasty, are the cornerstone of management. Although there are no randomized controlled trials assessing the efficacy of ERTs for DCI and their impact on subarachnoid hemorrhage outcomes, survey studies suggest that they are widely used in clinical practice with significant variability worldwide. IA vasodilators are first line ERTs, with better safety profiles and access to distal vasculature. The most commonly used IA vasodilators include calcium channel blockers, with milrinone gaining popularity in more recent publications. Balloon angioplasty achieves better vasodilation compared with IA vasodilators but is associated with higher risk of life-threatening vascular complications and is reserved for proximal severe refractory vasospasm. The existing literature on DCI rescue therapies is limited by small sample sizes, significant variability in patient populations, lack of standardized methodology, variable definitions of DCI, poorly reported outcomes, lack of long-term functional, cognitive, and patient-centered outcomes, and lack of control groups. Therefore, our current ability to interpret clinical results and make reliable recommendations regarding the use of rescue therapies is limited. This review summarizes existing literature on rescue therapies for DCI, provides practical guidance, and identifies future research needs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.