Evidence map›Paper›PMID 37231221›Full record

Trial reportInternational journal of behavioral medicine2024

A Preliminary Examination of the Effects and Mechanisms of Cognitive Behavioral Therapy for Insomnia on Systemic Inflammation Among Patients with Knee Osteoarthritis.

Chung Jung Mun, Traci J Speed, Patrick H Finan, Timothy H Wideman, Phillip J Quartana, Michael T Smith

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of behavioral medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00592449 (Sleep Disturbance, Central Pain Modulation, and Clinical Pain in Osteoarthritis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00592449 nacompletednot on this map

Sleep Disturbance, Central Pain Modulation, and Clinical Pain in Osteoarthritis (The SOAP Study)

TypeinterventionalSponsorJohns Hopkins UniversityRan2008 to 2014Enrolled209ConditionsSleep Initiation and Maintenance Disorders, OsteoarthritisArmsCognitive behavioral therapy (CBT) for insomnia, Behavioral desensitization treatment for insomnia
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Chung Jung MunEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, USA. cjmun@asu.edu.ORCID http://orcid.org/0000-0002-2439-8100
Traci J SpeedDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA.
Patrick H FinanDepartment of Anesthesiology, University of Virginia School of Medicine, Charlottesville, USA.
Timothy H WidemanSchool of Physical and Occupational Therapy, McGill University, Montreal, Canada.
Phillip J QuartanaCenter for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, USA.
Michael T SmithEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, USA.
Johns Hopkins University · USArizona State University · USMcGill University · CAUniversity of Virginia · USWalter Reed Army Institute of Research · US

Funding

Sleep Disturbance, Central Pain Modulation, and Clinical Pain in OsteoarthritisR01AR054871 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI SMITH, MICHAEL T · 2007 to 2011
$3.1M
NIAMS NIH HHS 5R01AR054871
6 · The paper itself

Abstract

backgroundSystemic inflammation, particularly the elevation of interleukin-6 (IL-6), plays an important role in the maintenance and progression of knee osteoarthritis. Insomnia, being highly prevalent in knee osteoarthritis, is understood to be a risk factor for systemic inflammation. The present study examined if cognitive behavioral therapy for insomnia (CBT-I) would reduce circulating IL-6 levels to a larger extent than the active control condition via greater improvement in sleep maintenance disturbance at mid-treatment, among individuals with knee osteoarthritis and insomnia disorder.

methodsThis is an ancillary study (N = 64) from a larger double-blind, randomized, active controlled clinical trial. Serum IL-6 was measured at baseline, post-treatment, and 3- and 6-month follow-ups. Sleep was measured by daily sleep diaries.

resultsOverall, there was no significant IL-6 trajectory differences between CBT-I and the active control (p = .64). Compared to the active control, CBT-I demonstrated greater improvement in sleep maintenance disturbance at mid-treatment (p = .01), which, in turn, was significantly associated with lower levels of IL-6 at 3-month follow-up (p < .05). Sleep maintenance disturbance at mid-treatment did not significantly predict changes in IL-6 levels at post-treatment (p = .43) and 6-month follow-up (p = .90).

conclusionsOur study demonstrates that CBT-I can be efficacious in improving sleep maintenance disturbance among individuals with knee osteoarthritis and insomnia disorder. However, no convincing evidence was found that CBT-I can substantially reduce IL-6 levels via improvement in sleep. CBT-I alone may not be effective in reducing systematic inflammation in this clinical population.

trial registrationNCT00592449.

Indexed as

Cognitive Behavioral TherapyOsteoarthritis, KneeSleep Initiation and Maintenance DisordersHumansInflammationInterleukin-6Treatment OutcomeInterleukin-6Cognitive behavioral therapyInflammationInsomniaInterleukin-6Osteoarthritis

Identifiers

PMID37231221
OpenAlexW4378195142

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.