Evidence map›Paper›PMID 37231190›Full record

ArticleAIDS and behavior2023

The Effect of COVID-19 Restrictions on General and HIV Positive Inpatient Admissions and Treatment Outcomes: An Uncontrolled Before-and-after Study at a Ugandan Tertiary Hospital.

Andrew Kazibwe, Bonniface Oryokot, Andrew Peter Kyazze, Philip Ssekamatte, George Patrick Akabwai, Emmanuel Seremba, David Mukunya, Magid Kagimu, Irene Andia-Biraro, Robert Kalyesubula

Open access · bronzeAbstract read
In one paragraph

Article in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Andrew KazibweCollege of Health Sciences, School of Medicine, Department of Medicine, Makerere University, P. O. Box 7072, Kampala, Uganda. kazibweandy@gmail.com.ORCID http://orcid.org/0000-0002-0738-8234
Bonniface OryokotThe AIDS Support Organisation (TASO), Programs Directorate, P. O. Box 10443, Kampala, Uganda.
Andrew Peter KyazzeTuberculosis and Comorbidities (TAC) Research Group, P. O. Box 7072, Kampala, Uganda.
Philip SsekamatteTuberculosis and Comorbidities (TAC) Research Group, P. O. Box 7072, Kampala, Uganda.
George Patrick AkabwaiCenter of Excellence, Baylor College of Medicine, P. O. Box 72025, Kampala, Uganda.
Emmanuel SerembaKiruddu National Referral Hospital, P. O. Box 6558, Kampala, Uganda.
David MukunyaFaculty of Health Sciences, Department of Public Health, Busitema University, P. O. Box 236, Tororo, Uganda.
Magid KagimuCollege of Health Sciences, School of Medicine, Department of Medicine, Makerere University, P. O. Box 7072, Kampala, Uganda.
Irene Andia-BiraroCollege of Health Sciences, School of Medicine, Department of Medicine, Makerere University, P. O. Box 7072, Kampala, Uganda.
Robert KalyesubulaCollege of Health Sciences, School of Biomedical Sciences, Department of Physiology, Makerere University, P. O. Box 7072, Kampala, Uganda.
Makerere University · UGBusitema University · UGThe AIDS Support Organization · UGUniversity of Suffolk · GB

Funding

Makerere University Research and Innovations Fund Makerere University Research and Innovations FundMulago Foundation Mulago Foundation
6 · The paper itself

Abstract

Measures to contain the Corona Virus Disease 2019 (COVID-19) pandemic curtailed access to prevention and treatment services for endemic infectious diseases like HIV. We used an uncontrolled before-and-after study design to compare general and HIV positive (HIV+) inpatient outcomes at a tertiary hospital in Uganda, using electronic records of medical inpatients. Data was downloaded, cleaned in Microsoft Excel, and exported to STATA for analysis. We determined the difference in number of admissions and median length of hospital stay using Mann-Whitney U test; and difference in median survival and incidence rates of mortality using Kaplan - Meier statistics, between the pre- and peri-COVID-19 groups. Of 7506 patients admitted to Kiruddu NRH, 50.8% (3812) were female and 18.7% (1,401) were aged 31-40 years, and 18.8% (1,411) were HIV+. Overall, 24.6% (1849) died. Total admissions were lower (2192 vs. 5314 patients), overall mortality rate higher (41.8% vs. 17.6%, p < 0.01), median length of hospital stay longer (6 vs. 4 days, p < 0.01) and median survival shorter (11 vs. 20 days, Chi-square = 252.05, p < 0.01) in the peri- than in pre-COVID-19 period. The adjusted hazard ratio (aHR) of death was 2.08 (95% CI: 1.85-2.23, p < 0.01) in the peri- compared to the pre-COVID-19 period. These differences were more pronounced in HIV + patients. Compared to pre-COVID-19, the peri-COVID-19 period registered lower inpatient admissions but poorer treatment outcomes for general and HIV + inpatients. Emerging epidemic responses should minimize disruption to inpatient care, especially for HIV + individuals.

Indexed as

COVID-19HIV InfectionsHospitalizationInpatientsAdolescentAdultFemaleHumansLength of StayMaleMiddle AgedSARS-CoV-2Tertiary Care CentersTreatment OutcomeUgandaYoung AdultAfricaCOVID19Health systemsHIV Care continuumHIV epidemiologyTreatment

Identifiers

PMID37231190
PMCPMC10211272
OpenAlexW4378174760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.