ArticleNature microbiology2023
Particular genomic and virulence traits associated with preterm infant-derived toxigenic Clostridium perfringens strains.
Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- Next-generation probiotics: an outlook into current applications and future developments.Nature reviews. Microbiology · 2026Review
- Identification and Genomic Localization of theMicroorganisms · 2026Article
- Virulence, antimicrobial resistance, and mobile genetic elements profile ofOne health (Amsterdam, Netherlands) · 2026Article
- Article
- Genetic background and plasmid-associated contig profiles of the beta-2 toxin coding genes cpb2 and atypical cpb2 in Clostridium perfringens.BMC genomics · 2026Article
- Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.Nature microbiology · 2026Article
- Early life bacteria and sibling exposure associate with restoration of the infant gut microbiome after cesarean section.Nature communications · 2026Article
- Genomic and clinical determinants of extraintestinalmedRxiv : the preprint server for health sciences · 2026Article
- Pathology and Cause of Death in Stranded Kogiids: A Retrospective Study from the Canary Islands (1999-2018).Animals : an open access journal from MDPI · 2026Article
- Toxin gene profiles, antibiotic resistance, and genetic diversity ofCurrent research in food science · 2026Article
- Type A and DFrontiers in cellular and infection microbiology · 2026Article
- Hyperbaric oxygen therapy for necrotizing fasciitis: a narrative review of mechanisms, clinical evidence, controversies, and practical considerations.Frontiers in cellular and infection microbiology · 2026Review
- Comprehensive analysis ofGut microbes · 2025Article
- Review: microbial metabolites - a key to address gut inflammation and barrier dysfunction in the premature infant.Gut microbes · 2025Review
- Article
- Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.Communications biology · 2025Article
- A Framework for Evaluation of New Processing Technologies in Human Milk Banking.Comprehensive reviews in food science and food safety · 2025Review
- Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants.Nature communications · 2025Article
- Comparative genomic analysis of Paraclostridium bifermentans in the intestinal microbiome of Hu sheep.Veterinary research communications · 2025Article
- Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis.Communications biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 1 country.
Funding
Abstract
Clostridium perfringens is an anaerobic toxin-producing bacterium associated with intestinal diseases, particularly in neonatal humans and animals. Infant gut microbiome studies have recently indicated a link between C. perfringens and the preterm infant disease necrotizing enterocolitis (NEC), with specific NEC cases associated with overabundant C. perfringens termed C. perfringens-associated NEC (CPA-NEC). In the present study, we carried out whole-genome sequencing of 272 C. perfringens isolates from 70 infants across 5 hospitals in the United Kingdom. In this retrospective analysis, we performed in-depth genomic analyses (virulence profiling, strain tracking and plasmid analysis) and experimentally characterized pathogenic traits of 31 strains, including 4 from CPA-NEC patients. We found that the gene encoding toxin perfringolysin O, pfoA, was largely deficient in a human-derived hypovirulent lineage, as well as certain colonization factors, in contrast to typical pfoA-encoding virulent lineages. We determined that infant-associated pfoA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.