Evidence map›Paper›PMID 37231082›Full record

ArticleScientific reports2023

Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke.

Zhu Zhu, Benjamin Vanderschelden, Sook Joung Lee, Haley Blackwill, Mohammad Shafie, Jennifer E Soun, Daniel Chow, Peter Chang, Dana Stradling, Tianchen Qian and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. A Mechanistic Review on Toxicity Effects of Methamphetamine.International journal of medical sciences · 2025
    Review
  4. Observational
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Zhu ZhuDepartment of Neurology, University of California Irvine, 200 S. Manchester Ave. Suite 206, Orange, CA, 92868, USA.
Benjamin VanderscheldenDepartment of Neurology, University of California Irvine, 200 S. Manchester Ave. Suite 206, Orange, CA, 92868, USA.
Sook Joung LeeDepartment of Neurology, University of California Irvine, 200 S. Manchester Ave. Suite 206, Orange, CA, 92868, USA.
Haley BlackwillDepartment of Neurology, University of California Irvine, 200 S. Manchester Ave. Suite 206, Orange, CA, 92868, USA.
Mohammad ShafieDepartment of Neurology, University of California Irvine, 200 S. Manchester Ave. Suite 206, Orange, CA, 92868, USA.
Jennifer E SounDepartment of Radiological Science, University of California, Irvine, CA, USA.
Daniel ChowDepartment of Radiological Science, University of California, Irvine, CA, USA.
Peter ChangDepartment of Radiological Science, University of California, Irvine, CA, USA.
Dana StradlingDepartment of Neurology, University of California Irvine, 200 S. Manchester Ave. Suite 206, Orange, CA, 92868, USA.
Tianchen QianDepartment of Statistics, University of California, Irvine, CA, USA.
Wengui YuDepartment of Neurology, University of California Irvine, 200 S. Manchester Ave. Suite 206, Orange, CA, 92868, USA. wyu@hs.uci.edu.
University of California, Irvine · USUniversity of California, Irvine Medical Center · USCatholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methamphetamine use causes spikes in blood pressure. Chronic hypertension is a major risk factor for cerebral small vessel disease (cSVD). The aim of this study is to investigate whether methamphetamine use increases the risk of cSVD. Consecutive patients with acute ischemic stroke at our medical center were screened for methamphetamine use and evidence of cSVD on MRI of the brain. Methamphetamine use was identified by self-reported history and/or positive urine drug screen. Propensity score matching was used to select non-methamphetamine controls. Sensitivity analysis was performed to assess the effect of methamphetamine use on cSVD. Among 1369 eligible patients, 61 (4.5%) were identified to have a history of methamphetamine use and/or positive urine drug screen. Compared with the non-methamphetamine group (n = 1306), the patients with methamphetamine abuse were significantly younger (54.5 ± 9.7 vs. 70.5 ± 12.4, p < 0.001), male (78.7% vs. 54.0%, p < 0.001) and White (78.7% vs. 50.4%, p < 0.001). Sensitivity analysis showed that methamphetamine use was associated with increased white matter hyperintensities, lacunes, and total burden of cSVD. The association was independent of age, sex, concomitant cocaine use, hyperlipidemia, acute hypertension, and stroke severity. Our findings suggest that methamphetamine use increases the risk of cSVD in young patients with acute ischemic stroke.

Indexed as

Cerebral Small Vessel DiseasesHypertensionIschemic StrokeMethamphetamineStrokeHumansMagnetic Resonance ImagingMaleMethamphetamine

Identifiers

PMID37231082
PMCPMC10212921
OpenAlexW4378218018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.