ArticleNature communications2023
Cryogenic electron ptychographic single particle analysis with wide bandwidth information transfer.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Sparse-Scan Ptychography with Hybrid-Overlap Scanning and Reference-Guided Probe Updates.Sensors (Basel, Switzerland) · 2026Article
- Electron fourier ptychography for phase reconstruction.Scientific reports · 2025Article
- Sub-ångström resolution ptychography in a scanning electron microscope at 20 keV.Nature communications · 2025Article
- Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy.Nature methods · 2025Article
- Roadmap for Quantum Nanophotonics with Free Electrons.ACS photonics · 2025Review
- Ptychoscopy: a user friendly experimental design tool for ptychography.Scientific reports · 2025Article
- Phase Imaging Methods in the Scanning Transmission Electron Microscope.Nano letters · 2025Review
- Extending the reach of single-particle cryoEM.Current opinion in structural biology · 2025Review
- Atomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography.Nature communications · 2025Article
- Review
- Ptychography at all wavelengths.Nature reviews. Methods primers · 2025Article
- Elemental mapping in single-particle reconstructions by reconstructed electron energy-loss analysis.Nature methods · 2024Article
- Zooming in and out: Exploring RNA Viral Infections with Multiscale Microscopic Methods.Viruses · 2024Review
- Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution.Nature communications · 2024Article
- X-Ray Multibeam Ptychography at up to 20 keV: Nano-Lithography Enhances X-Ray Nano-Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Integrative Approaches to Study Virus Structures.Sub-cellular biochemistry · 2024Review
- Cryo-electron tomography to study viral infection.Biochemical Society transactions · 2023Review
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
Abstract
Advances in cryogenic transmission electron microscopy have revolutionised the determination of many macromolecular structures at atomic or near-atomic resolution. This method is based on conventional defocused phase contrast imaging. However, it has limitations of weaker contrast for small biological molecules embedded in vitreous ice, in comparison with cryo-ptychography, which shows increased contrast. Here we report a single-particle analysis based on the use of ptychographic reconstruction data, demonstrating that three dimensional reconstructions with a wide information transfer bandwidth can be recovered by Fourier domain synthesis. Our work suggests future applications in otherwise challenging single particle analyses, including small macromolecules and heterogeneous or flexible particles. In addition structure determination in situ within cells without the requirement for protein purification and expression may be possible.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.