Evidence map›Paper›PMID 37230968›Full record

ReviewSignal transduction and targeted therapy2023

Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome.

Renjun Lv, Xueying Liu, Yue Zhang, Na Dong, Xiao Wang, Yao He, Hongmei Yue, Qingqing Yin

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Signal transduction and targeted therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07132307 (Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through), which is not on this map. Cited by 296 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
296citing papers in PubMed, 16 pooled it
66.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07132307 narecruitingnot on this mapstarted 2025, after this paper: background citation

Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2027Enrolled30ConditionsObstructive Sleep ApneaArmsMandibular advancement device (MAD)
3 · Its place in the literature

Who cites it

296 citing papers in PubMed, 16 syntheses or guidelines pooled it, 380 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Multichannel machine learning for polysomnographic diagnosis of obstructive sleep apnea: a Bayesian meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Trial
  18. Trial
  19. Trial
  20. Trial

236 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Renjun LvThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Xueying LiuDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Yue ZhangDepartment of Geriatrics, the 2nd Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Na DongThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Xiao WangThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Yao HeThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Hongmei YueDepartment of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, 730000, China. yuehongmei18@sina.com.
Qingqing YinDepartment of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China. yinqingqing@sdfmu.edu.cn.
Lanzhou University · CNShandong First Medical University · CNChinese PLA General Hospital · CNFirst Hospital of Lanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The prevalence of OSAS continues to rise worldwide, particularly in middle-aged and elderly individuals. The mechanism of upper airway collapse is incompletely understood but is associated with several factors, including obesity, craniofacial changes, altered muscle function in the upper airway, pharyngeal neuropathy, and fluid shifts to the neck. The main characteristics of OSAS are recurrent pauses in respiration, which lead to intermittent hypoxia (IH) and hypercapnia, accompanied by blood oxygen desaturation and arousal during sleep, which sharply increases the risk of several diseases. This paper first briefly describes the epidemiology, incidence, and pathophysiological mechanisms of OSAS. Next, the alterations in relevant signaling pathways induced by IH are systematically reviewed and discussed. For example, IH can induce gut microbiota (GM) dysbiosis, impair the intestinal barrier, and alter intestinal metabolites. These mechanisms ultimately lead to secondary oxidative stress, systemic inflammation, and sympathetic activation. We then summarize the effects of IH on disease pathogenesis, including cardiocerebrovascular disorders, neurological disorders, metabolic diseases, cancer, reproductive disorders, and COVID-19. Finally, different therapeutic strategies for OSAS caused by different causes are proposed. Multidisciplinary approaches and shared decision-making are necessary for the successful treatment of OSAS in the future, but more randomized controlled trials are needed for further evaluation to define what treatments are best for specific OSAS patients.

Indexed as

COVID-19Sleep Apnea, ObstructiveAgedHumansHypoxiaMiddle AgedObesityPharynx

Identifiers

PMID37230968
PMCPMC10211313
OpenAlexW4378175764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.