Evidence map›Paper›PMID 37230388›Full record

ArticleThe Journal of biological chemistry2023

The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.

Junjun Li, Jin Peng, Lingzhi Wu, Xiang Shen, Xinghua Zhen, Yimao Zhang, Huailu Ma, Yongfeng Xu, Qunli Xiong, Qing Zhu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Junjun LiZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China.
Jin PengZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Lingzhi WuZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xiang ShenChaser Therapeutics Inc., Hangzhou, Zhejiang, China.
Xinghua ZhenZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yimao ZhangDepartment of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
Huailu MaInstitute of Translational Medicine, Zhejiang University Medical School, Hangzhou, Zhejiang, China.
Yongfeng XuDepartment of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China.
Qunli XiongDepartment of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China.
Qing ZhuDepartment of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China. Electronic address: newzhuqing1972@163.com.
Pumin ZhangZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Translational Medicine, Zhejiang University Medical School, Hangzhou, Zhejiang, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: pzhangbcm@zju.edu.cn.
Sichuan University · CNFirst Affiliated Hospital Zhejiang University · CNZhejiang Chinese Medical University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is one of the most common extracranial solid tumors in children. MYCN gene amplification is highly associated with poor prognosis in high-risk NB patients. In non-MYCN-amplified high-risk NB patients, the expression of c-MYC (MYCC) and its target genes is highly elevated. USP28 as a deubiquitinase is known to regulate the stability of MYCC. We show here USP28 also regulates the stability of MYCN. Genetic depletion or pharmacologic inhibition of the deubiquitinase strongly destabilizes MYCN and stops the growth of NB cells that overexpress MYCN. In addition, MYCC could be similarly destabilized in non-MYCN NB cells by compromising USP28 function. Our results strongly suggest USP28 as a therapeutic target for NB with or without MYCN amplification/overexpression.

Indexed as

Neural Stem CellsNeuroblastomaCell Line, TumorChildDeubiquitinating EnzymesGene Expression Regulation, NeoplasticHumansN-Myc Proto-Oncogene ProteinTranscription FactorsUbiquitin ThiolesteraseDeubiquitinating EnzymesMYCN protein, humanN-Myc Proto-Oncogene ProteinTranscription FactorsUbiquitin ThiolesteraseUSP28 protein, humandeubiquitinationMYCNneuroblastomaubiquitinUSP28

Identifiers

PMID37230388
PMCPMC10404617
OpenAlexW4377861336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.